Lecture 6 humoral immune response
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Lecture 6 Humoral Immune Response. The Antibody Response. Antibody Protection of the Host. Immunologic Memory. Virgin lymphocyte pool . PRIMARY RESPONSE . effector cells . memory cell pool . SECONDARY RESPONSE. effector cells . memory cell pool . Immunologically Naive.

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Lecture 6 humoral immune response l.jpg
Lecture 6Humoral Immune Response




Immunologic memory l.jpg
Immunologic Memory

Virgin lymphocyte pool

PRIMARY RESPONSE

effector cells

memory cell pool

SECONDARY RESPONSE

effector cells

memory cell pool


Immunologically naive l.jpg
Immunologically Naive

No previous experience

No memory

Must be educated


The primary immune response l.jpg
The Primary Immune Response

antibody titer

lag

log phase

plateau

decline

time

antigen challenge


Class switching l.jpg
Class Switching

antibody titer

IgM

IgG

time


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Four phases of the primary response

  • a lag phase where no antibody is detected

  • a log phase in which the antibody titer rises logarithmically

  • a plateau phase during which the antibody titer stabilizes

  • a phase (decline) during which the antibody is cleared or catabilized


The anamnestic immune response l.jpg
The Anamnestic Immune Response

Secondary Response

antibody titer

1000

100

Primary Response

10

1

Time


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Comparison of Primary and Secondary Responses

  • Time course

  • Antibody titer

  • Antibody class

  • Antibody affinity


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Terms to remember

  • Opsonization

  • Neutralization

  • Complement activation

  • Primary response

  • Secondary/ anamnestic/ booster response

  • Lag phase

  • Log phase

  • Plateau period

  • Memory cells

  • Class switching

  • Affinity maturation/ change in affinity with time


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