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Chemical Substances TLV ® Committee. Lisa Brosseau, ScD, CIH Associate Professor University of Minnesota Chair, TLV ® -CS Committee. ACGIH ® Committees. Committees consist of members, who volunteer time toward developing scientific guidelines and publications

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chemical substances tlv committee

Chemical Substances TLV® Committee

Lisa Brosseau, ScD, CIH

Associate Professor

University of Minnesota

Chair, TLV®-CS Committee

acgih committees
ACGIH®Committees
  • Committees consist of members, who volunteer time toward developing scientific guidelines and publications
    • Primary goal is to serve the scientific needs of occupational hygienists
    • Committee expenses (travel) are supported by ACGIH®
    • Time is donated by the members
a short historical perspective
A Short Historical Perspective
  • 1941 TLV® Committee Created
    • Committee of Technical Standards creates Subcommittee on Threshold Limits (becomes independent committee in 1944)
  • 1946 List Published
    • First published list of “Maximum Allowable Concentrations” (MACs) for 150 chemical substances (renamed Threshold Limit Values in 1948)
history
History
  • 1955 Written Documentation
    • TLV® Committee begins to write Documentation for each TLV® (207 completed by 1958)
    • Published 1st edition in 1962 (257 substances)
history5
History
  • Important Additions and Changes
    • 1961 - Skin Notation
    • 1962 - Carcinogens Appendix
    • 1963 - Excursion factors
    • 1964 - Notice of Intended Changes
          • 1968 - TLVs® for Physical Agents Committee
    • 1972 - Cancer classifications defined
    • 1980 - Operational guidelines & procedures
    • 1981 - List of Substances & Issues Under Study
history6
History
  • More Changes
    • 1983 - Established Biological Exposure Indices (BEI®) Committee
    • 1993 - Deleted STELS for many substances
    • 1995 - CD-ROM
    • 1998 - Reformatted TLV® Book to include information on “TLV® Basis - Critical Effects”
committee structure
Committee Structure
  • Chair
    • Recommendations from Committee & Staff; Board appoints
  • Vice-Chair, Subcommittee Chairs, Members
    • Recommended by Chair, appointed by Board
  • Three Subcommittees, each with Chair
    • Dusts & Inorganics (D&I)
    • Hydrogen, Oxygen & Carbon Compounds (HOC)
    • Miscellaneous Compounds (MISCO)
  • Staff Support (Liaison, Clerical, Literature Searching)
chemical substance subcommittees
Chemical Substance Subcommittees
  • Approximately 10 members on each
  • Membership from academia, government, unions, industry
  • Membership represents four key disciplines:
    • Industrial Hygiene
    • Toxicology
    • Occupational Medicine
    • Occupational Epidemiology
other subcommittees
Other Subcommittees
  • Chemical Selection
    • Recommendations to HOC, D&I, MISCO
  • Membership
    • Recruitment, screening, recommendations
  • Notations
    • Definitions, new proposals
  • Communications
    • Explaining our decisions
committee structure10

Board of Directors

Committee Structure

Staff

Chair of TLV® Committee

Administrative Subcommittees

(Membership, Chemical Selection)

Steering Committee

Dust & Inorganics Subcommittee(D&I)

Hydrogen, Oxygen, Carbon Subcommittee (HOC)

Miscellaneous Compounds Subcommittee

(MISCO)

tlv development process
TLV® Development Process

Draft

Doc.

Under Study

List

Committee Review

& Revision

External

Input

Committee Review

& Revision

Committee

& Board

Approval

NIC

Committee

& Board

Approval

Adopted

Value

tlvs defined
TLVs® Defined
  • TLV® — more than just

“THE NUMBER”

  • Documentation describes:
    • Critical health effects
    • Quality of the data relied upon and areas of uncertainty
    • Possible sensitive subgroups
    • Type of TLV® (TWA, STEL, C) and reason for selection
    • Notations
core tlv principles
Core TLV® Principles
  • Focus on airborne exposures in occupational settings
  • Utilize the “threshold” concept
  • Primary users are industrial hygienists
  • Goal is toward protection of “nearly all” workers

Technical, economic, and analytic feasibility are NOT considered

slide14

The Essential Ingredients for Developing TLVs®

Published / Peer Reviewed Science

+

Dedicated Volunteerism

+

Professional Integrity

& Judgment

warnings
Warnings
  • NOT to be used as an index of relative toxicity
  • NOT for estimating toxic potential of continuous, uninterrupted exposures or other extended work periods
  • NOT as proof/disproof of existing disease
  • NOT to evaluate or control air pollution
  • NOT legal standards
summary
Prefer human over animal data

Use uncertainty factors, if necessary (but no “rules”)

Look for threshold of effects

Consider irritation an important health endpoint

Not concerned with levels of risk

Look for the “worst case” health endpoint

Always select an exposure level

Explain the reasons for our recommendations

Summary