slide1 n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
New Frontiers in Systems Biology PowerPoint Presentation
Download Presentation
New Frontiers in Systems Biology

Loading in 2 Seconds...

play fullscreen
1 / 27

New Frontiers in Systems Biology - PowerPoint PPT Presentation


  • 84 Views
  • Uploaded on

New Frontiers in Systems Biology. John J. Tyson. Department of Biology and Virginia Bioinformatics Institute Virginia Polytechnic Institute and State University Blacksburg, Virginia. Systems Science.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'New Frontiers in Systems Biology' - damita


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide1

New Frontiers in

Systems Biology

John J. Tyson

Department of Biology

and

Virginia Bioinformatics Institute

Virginia Polytechnic Institute and State University

Blacksburg, Virginia

slide2

Systems Science

…the use of mathematics to study how the parts of a complex system fit together to function in ways that transcend the properties of the individual parts.

slide3

Systems Science is the flip-side of Reductionist Science.

reductionist

science

(parts)

systems

science

(whole)

Norbert Weiner (1948)

Cybernetics: Control & Communication in the Animal and the Machine

slide4

Outline

Weather Forecasting

Traditional Systems Biology

“New” Systems Biology

slide5

The map is a snapshot of the highs and lows at one instant; weather is a dynamic process…the movement of air masses in time across the continent.

Weather Forecasting

slide6

Navier-Stokes

Equations

Modern weather prediction is based on accurate

computer “simulations” of moving air masses.

Weather Forecasting

slide7

Weather Forecasting

Accurate weather forecasting

is essential to modern…

Transportation industry

Military planning

Civil defense

slide8

Biological Systems

Ecosystems

Odum, MacArthur,

Wilson, May, …

Infectious disease

slide9

Biological Systems

Ecosystems Organ systems

Entelos: math model of human digestive system—

diabetes, obesity

slide10

Biological Systems

Organ systems

Ecosystems

Animal cell

“Systems-level” thinking has been slow to catch on because…

slide11

… the “parts list” was missing

1985-2000: The era of reductionist molecular biology; discovery of the parts list (proteins and the genes that encode them); culminating in the complete sequence of the human genome.

slide12

New Systems Biology

…the use of mathematics to study how genes and proteins interact to produce the complex behaviors of a living cell…

movement

energy supply

signaling

growth

division

death

slide13

External

signals

Growth

Development

Division

Reproduction

Death

Information

Processing

System

Cell signaling

Hanahan & Weinberg (2000)

slide14

Division

Reproduction

Cell signaling

Hanahan & Weinberg (2000)

slide15

The Budding Yeast Cell Cycle

budding

DNA synthesis

growth

mitosis

newborn cell

cell division

slide16

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Cell division

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide17

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Cell division

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide18

synthesis

synthesis

binding

degradation

degradation

inactivation

activation

The mathematical model

slide19

G1

S/M

mass

CKI

Cln2

Clb2

Cdh1

Cdc20

Time (min)

slide20

46,000

Full Details: http://mpf.biol.vt.edu

slide21

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Sister chromatid separation

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Mutants

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide22

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Sister chromatid separation

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Mutants

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide23

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Sister chromatid separation

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Mutants

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide24

Pds1

Esp1

Cdc14

RENT

Sic1

Sic1

P

Esp1

Sister chromatid separation

unaligned chromosomes

SBF

Cdh1

Pds1

Mcm1

Cdc20

PPX

Net1P

Mutants

Tem1-GDP

Cdc15/MEN

Lte1

Bub2

Tem1-GTP

Net1

Mcm1

Cdh1

Cdc20

Cln2

Clb2

Clb5

Mitosis

Mad2

growth

APC-P

unaligned chromosomes

Mcm1

Cdc20

Cdh1

Clb2

APC

Inactive trimer

Cdc14

and

Cln3

Swi5

CDKs

SCF

P

Cdc14

Bck2

Inactive trimer

?

MBF

Clb5

DNA synthesis

Clb2

SBF

Cln2

Budding

slide25

Accurate account of the properties of >100 mutant cells; correctly predicts properties of new mutant combinations

slide26

Designer

Drugs

Taxol

Cancer

Information

Processing

System

What use is the new systems biology?

Hanahan & Weinberg (2000)

slide27

The impact of the new systems biology on biomedicine, pharmaceuticals and homeland security may, some day, be as great as the impact of modern weather prediction on transportation, military preparedness and civil defense.