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Interpenetrating Networks for Delivery Systems

This project aims to create a unique delivery mechanism for reconstituting interpenetrating networks using bifunctional PEG linkers, gelatin backbone, and UV curing for improved drug delivery. The approach involves addressing design constraints, exploring various design approaches, and presenting preliminary data for further development and clinical applications of IPNs.

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Interpenetrating Networks for Delivery Systems

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  1. Interpenetrating Networks for Delivery Systems Client: Professor John W. Kao Advisor: Professor Kristyn Masters Claire Flanagan Ashley Huth Max Michalski Adam Rieves

  2. Overview • Problem Statement • Background Information • Design Constraints • Design Approaches • Preliminary Data • Conclusions

  3. Problem Statement • Our goal is to create a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).

  4. InterpenetratingNetwork (IPN) Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands BiodegradableGelatin Backbone Bifunctional PEG Linkers PEG-diacrylate (2-3.4 kDa ) Soluble Therapeutic(s) in situ UV curing Solution (drugs + matrix component) *Kao, W.J

  5. Conventional Dressings IPN Irregular Wound Clinical Applications • Benefits • Moist healing environment • Conforms to irregular wounds • Covers large surface areas • Delivers drug cocktails • Very biocompatible • Issues • Uneven administration • Reconstitution Method • Heat • Time • Shelf life *Kao, W.J.

  6. Ideal ClinicalAdministration Mix 1 ingredients w/ drug(s) in one container 2 Shake 3 Spray with a controlled distribution over irregular wound surface 4 Cure in 30 sec to obtain a rubbery film 7 Clean 6 Sustained Release while the IPN biodegrades 5 Cover Day 7 Day 1 Day 3 *Kao, W.J

  7. Design Constraints • Clinically applicable • No special equipment required • Simple reconstitution methods • Administration via spray bottle • Completely reconstitutes • Meets viscosity requirements • Cure time < 60 seconds • Improves Shelf Life

  8. Exothermic Reaction Resistive Element Pros Feasibility Viscosity Passive Procedure Cons Cost Client Preference Safety Approach 1: Heating Element

  9. Alter pH Add Surfactants Try Buffer Varieties Pros Client Preference Reconstitution Time Cost Cons Feasibility Safety Active Procedure Approach 2: Research

  10. Design Matrix

  11. Preliminary Data **Water at 60 ºC

  12. Preliminary Data **All solutions at room temperature **Final solution 10% gelatin

  13. Conclusions • We hope to further the clinical applications of IPNs • Future Work • Continue literature research • Gather data • Test complete IPNs • Reconsider design approach

  14. Questions ?

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