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Interpenetrating Networks for Delivery Systems. Client: Professor John W. Kao Advisor: Professor Kristyn Masters Claire Flanagan Ashley Huth Max Michalski Adam Rieves. Overview. Problem Statement Background Information Design Constraints Design Approaches Preliminary Data Conclusions.

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interpenetrating networks for delivery systems

Interpenetrating Networks for Delivery Systems

Client: Professor John W. Kao

Advisor: Professor Kristyn Masters

Claire Flanagan

Ashley Huth

Max Michalski

Adam Rieves

overview
Overview
  • Problem Statement
  • Background Information
  • Design Constraints
  • Design Approaches
  • Preliminary Data
  • Conclusions
problem statement
Problem Statement
  • Our goal is to create a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).
interpenetrating network ipn
InterpenetratingNetwork (IPN)

Covalently Linked Therapeutic(s) and/or

Cell Adhesion Ligands

BiodegradableGelatin Backbone

Bifunctional PEG Linkers

PEG-diacrylate

(2-3.4 kDa )

Soluble Therapeutic(s)

in situ

UV curing

Solution

(drugs +

matrix component)

*Kao, W.J

clinical applications

Conventional Dressings

IPN

Irregular Wound

Clinical Applications
  • Benefits
    • Moist healing environment
    • Conforms to irregular wounds
    • Covers large surface areas
    • Delivers drug cocktails
    • Very biocompatible
  • Issues
    • Uneven administration
    • Reconstitution Method
      • Heat
      • Time
    • Shelf life

*Kao, W.J.

ideal clinical administration
Ideal ClinicalAdministration

Mix

1

ingredients w/

drug(s) in one

container

2

Shake

3

Spray

with a controlled distribution over irregular wound surface

4

Cure

in 30 sec to obtain a rubbery film

7

Clean

6

Sustained Release

while the IPN biodegrades

5

Cover

Day

7

Day

1

Day

3

*Kao, W.J

design constraints
Design Constraints
  • Clinically applicable
    • No special equipment required
    • Simple reconstitution methods
  • Administration via spray bottle
  • Completely reconstitutes
  • Meets viscosity requirements
  • Cure time < 60 seconds
  • Improves Shelf Life
approach 1 heating element
Exothermic Reaction

Resistive Element

Pros

Feasibility

Viscosity

Passive Procedure

Cons

Cost

Client Preference

Safety

Approach 1: Heating Element
approach 2 research
Alter pH

Add Surfactants

Try Buffer Varieties

Pros

Client Preference

Reconstitution Time

Cost

Cons

Feasibility

Safety

Active Procedure

Approach 2: Research
preliminary data
Preliminary Data

**Water at 60 ºC

preliminary data1
Preliminary Data

**All solutions at room temperature

**Final solution 10% gelatin

conclusions
Conclusions
  • We hope to further the clinical applications of IPNs
  • Future Work
    • Continue literature research
    • Gather data
    • Test complete IPNs
    • Reconsider design approach