THE QUEST FOR CLINICAL BENEFIT. Steven Osborne, M.D. Medical Officer Division of Over-The-Counter Drug Products. Nonprescription AC Meeting March 23, 2005. Key Issues. Do Clinical Trials Assessing Infection Rates Provide Definitive Evidence Of Clinical Benefit?. Key Issues.
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Steven Osborne, M.D.
Division of Over-The-Counter Drug Products
Nonprescription AC Meeting
March 23, 2005
Group Gram PositiveGram NegativeSpeed of Action
Alcohols +++ +++ Fast
Chlorhexidine +++ ++ Intermediate
Iodine Compounds +++ +++ Intermediate
Iodophors +++ +++ Intermediate
Phenol Derivatives +++ + Intermediate
Triclosan +++ ++ Intermediate
Quaternary AC + ++ Slow
+++ excellent, ++ good, but does not include entire bacterial spectrum,