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b 3

H1. b 3. b 1. b 2. b 8. b 5. b 10. b 6. b 4. b 9. C-Loop. b 7. Cys loop. M3. M1. M2. M4.

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b 3

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  1. H1 b3 b1 b2 b8 b5 b10 b6 b4 b9 C-Loop b7 Cys loop M3 M1 M2 M4

  2. 10 20 30 40 50 60 MRCSPGGVWLALAASLLHVSLQG EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNH1 b170 80 90 100 110 120 130QVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQb2 b3 b4 b5140 150 160 170 180 190 200YLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFb6 Cys loop b7 b8 b9 210 220 230 240 250 260 270YECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVC-loopb10M1M2280 290 300 310 320 330 340 AEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHD PDGGKMPKWTRVILLNWCAWFLRMKRPM3 350 360 370 380 390 400 410 GEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEVestibule 420 430 440 450 460 470 480HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFA ACVVDRLCLMAFSVFTIICTIGILM4 490 MSAPNFVEAVS KDFA

  3. A C B

  4. A B C D

  5. C-Loop moves out A B E D A C B C-Loop moves out C-loop in A, C & E remain in position. (some motion does occur in other loops) C D D E A C B A, C & E remain relatively stationary. B & D rotate and move in to close the pore.

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