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Bioinformatics for Vet. Review 1st. Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 [email protected] Growth of GenBank. 1982: 600,000 Bases 2002: 28.5 Billion Bases. Image source: www.ncbi.nlm.nih.gov. What is bioinformatics?.

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bioinformatics for vet review 1st

Bioinformatics for Vet. Review 1st

Sung Youn Lee, PhD. Student

Veterinary collage, Room 320

02 450 3719, 016 293 6059

[email protected]

growth of genbank
Growth of GenBank
  • 1982: 600,000 Bases
  • 2002: 28.5 Billion Bases

Image source: www.ncbi.nlm.nih.gov

what is bioinformatics
What is bioinformatics?
  • Bio(Biology) - informatics (information science)
  • The computational branch of molecular biology.
    • in vivo
    • in vitro
    • in silico
  • Computational biology: development of algorithms and statistical models to analyze biological data
  • Bioinformatics/Computational Biology will be interchanged
central dogma
Central Dogma

DNA

RNA

PROTEIN

Image source: unknown

double helix
Double Helix
  • Two complementary DNA strands form a stable DNA double helix
  • Spring 2003 marked the 50th anniversary of its discovery

Image source; www.ebi.ac.uk/microarray/ biology_intro.htm

rna secondary structure
RNA secondary structure
  • E. coli Rnase P RNA secondary structure

Image source: www.mbio.ncsu.edu/JWB/MB409/lecture/ lecture05/lecture05.htm

the peptide bond
The Peptide Bond
  • Dehydration synthesis
  • Repeating backbone: N–C –C –N–C –C
    • Convention – start at amino terminus and proceed to carboxy terminus

O

O

proteins are chains of amino acids
Proteins are chains of amino acids
  • Polymer– a molecule composed of repeating units
question answer
Question & Answer
  • Adenine vs Adenosine

Adenosine

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