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FP7 FMTXCT Project UMCE-HGUGM first year activity report Partner FIHGM. Laboratorio de Imagen M é dica. Medicina Experimental Hospital Universitario Gregorio Mara ñó n, Madrid. Workpackage 2: XCT development Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT.

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Fp7 fmtxct project umce hgugm first year activity report partner fihgm

FP7 FMTXCT ProjectUMCE-HGUGM first year activity report Partner FIHGM

Laboratorio de Imagen Médica. Medicina Experimental

Hospital Universitario Gregorio Marañón, Madrid


Fp7 fmtxct project umce hgugm first year activity report partner fihgm


Workpackage 2 xct development
Workpackage 2: XCT development

  • Use of X-ray contrast agents

  • Double exposure techniques

  • Dual energy X-ray source


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

CT System Outline

Mechanical Design



Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Detector Dynamic Range Expansion

Dual-Exposure technique

  • Main features

  • Two datasets acquired

    • First

      • Low SNR for dense materials

      • Detector not saturated for soft materials

    • Second

      • High SNR for dense materials

      • Detector saturated for soft materials

  • Same X-ray beam spectral properties

  • Different photon flux


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Detector Dynamic Range Expansion

Dual-Exposure technique

Dataset #1

Dataset #2


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Detector Dynamic Range Expansion

Dual-Exposure technique (work in progress)

Dual exposure

Single exposure

CNR (PTFE/Air) = 22.11

CNR (PTFE/Air) = 13.91


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Multi-Energy data acquisition/processing

Simulated Spectra for the new tube

  • Changing filter setting

Mean Energy = 55.6 kV

Mean Energy = 66.1 kV

Spectral simulations carried out using SPEKTR software libraries

Siewerdsen, et.al., “Spektr: A computational tool for x-ray spectral analysis and imaging system optimization”, Med. Phys.31(9), 2004


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Multi-Energy data acquisition/processing

Simulated Spectra for the new tube

  • Changing X-ray tube setting

Mean Energy = 34.9 kV

Mean Energy = 66.1 kV


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Use of X-ray contrast agents

Fenestra Iopamiro


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Mouse

200 µA, voltage 50 kV

200 µm

Fenestra LC

Mouse

200 µA, voltage 50 kV

200 µm

Iopamiro


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Mouse

200 µA, voltage 50 kV

200 µm

Iopamiro

Dynamic study


Workpackage 8 fmt xct imaging accuracy versus pet xct
Workpackage 8: FMT-XCT imaging accuracy versus PET-XCT


Materials selection for the optical phantom construction
Materials selection for the optical phantom construction

Silicon Ti02 Pro Jet

Polyester resin

Bulk materials

Scatterers

Absorbers

+

+

Lipid emulsions

(Intralipid)

Polymer microspheres

India ink

Water

Gelatin


Things to have in mind when designing a fmt phantom

Resolution is depth dependent

Diffusion approximation: One photon mean free path ≈ 1mm

Source

Things to have in mind when designing a FMT phantom.

Source

Detector



Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Fluorescent spheres, 2 mm

(Should their size vary?)

Heterogeneities

4 mm

Phantom design



How to insert the fluorophore in the phantom
How to insert the fluorophore in the phantom?

Resin vs Silicon

- Mix the fluorophore with the bulk material*

- Capillaries (diffusive-non diffusive interfaces)

- Pellets

* John Baeten et al “Development of fluorescent materials for Diffuse Fluorescence Tomography standars and phantoms” Optics express vol 15 2007


What to measure
What to measure

Resolution. FWHM of point-like source?

Quantification accuracy

Sensitivity: In-vivo specific application

PET phantom remarks



Pet phantom
PET phantom imaging situation”?


Pet phantom1
PET phantom imaging situation”?


Pet phantom2
PET phantom imaging situation”?


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

Detector Dynamic Range Expansion imaging situation”?

Dual-Exposure technique

  • Main features

  • X-ray tube current calculation for the second scan

    • Based on Histogran processing

    • Shift the histogram to place 75% of the total value into the High-Gain region

  • Dataset combination

    • Detector Model

    • Image combination based on a Maximum-Likelihood calculation assuming Independent Gaussian distribution.

  • i : Acquisition number

  • j : Pixel number

  • A: Current value

  • N: Noise value


Fmt system
FMT system imaging situation”?


Fp7 fmtxct project umce hgugm first year activity report partner fihgm

coronal Z=0.25 cm imaging situation”?

Resultados preliminares, maniquíes:

Planar imaging

Agar based, TiO2 (scatter), Blank ink (absorption)