Free curcuminoid | Curcumin for joint health

1. CURQFEN® - RISING TO NEW HEIGHTS IN FREE CURCUMINOIDS DELIVERY www.curqfen.net

3. CurQfen® - Rising to new heights in free curcuminoids delivery A large number of in-vitro studies have revealed intriguing pharmacodynamics of curcumin as a neuroprotective agent, specifically confirming the modulation of genes, proteins, transcription factors, and neurotransmitters at the mitochondrial level in support of curcumin’s possible positive influence on various brain health functions like neuro inflammation, neurodegenerative etc. The real challenge is delivering the free form of curcumin (unconjugated form) to the targeted brain tissues. The native form of curcumin is BBB permeable. But once it has undergone biotransformation (metabolized into glucuronides) the ability to pass the barrier is lost since the conjugated metabolites are bulky water-soluble molecules and undergoes quick renal clearance. Another point to be noted is that consumption of high dosage of unformulated curcumin 95 has shown to deliver some amount unconjugated free forms (less than 10 ng/g level) to the brain tissues when analyzed by sensitive tandem mass spectrometric tools. Thus, any formulation having unformulated curcumin 95 can deliver trace amount of neuro protection, provided if we consume high dosage and the effects will be quite marginal. Here comes the real-world significance of a formulation which can deliver significant amount of free curcuminoids to the brain tissue without having the burden of high dose. CurQfen® was the solution for this dilemma. CurQfen®, a new generation curcumin for brain health & joint health which is a green formulation of curcumin and de-bitter fenugreek fibre as self-emulsifying hydrogel scaffold, is capable of delivering high level of BBB-permeable ‘free curcumin’ even at a low dosage of 250mg single dose (Kumar et al., 2016).