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Current National and International Scientific Radon-Related Activities and Educational Initiatives Keynote Address. R. William Field, Ph.D., M.S. Associate Professor Department of Occupational and Environmental Health Department of Epidemiology College of Public Health 104 IREH
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Current National and International Scientific Radon-Related Activities and Educational Initiatives
R. William Field, Ph.D., M.S.
Department of Occupational and Environmental Health
Department of Epidemiology
College of Public Health
University of Iowa
Iowa City, IA 52242
Fifteenth National Radon Meeting
Shelter Pointe Hotel and Marina
San Diego, California
September 25–28, 2005
Pooling (Laboratory and Field Studies - Steck)
1556 Agricola - Miners in Europe
1879 Harting & Hesse - Lung Cancer in Miners
1921 Uhlig - Radium Emanations & Lung Cancer
1950s Peller - First Review of Mining Related Cancers
1970s Studies of Underground Miners (ongoing)
1990s Residential Radon Studies
1994 NCI Pooled Analyses of Miners
1999 NAS BEIR VI Report
2005 North American and European Pooled
Residential Radon Studies
2007 Global Pooling of Residential Radon Studies
2007 Pooling of Glass-based Residential Radon
Radon in homes and risk of lung cancer:
European case-control studies collaborative
analysis of individual data from 13 European
S Darby, D Hill, A Auvinen, J M Barros-Dios, H Baysson, F Bochicchio, H Deo, R Falk, F Forastiere, M Hakama, I Heid, L Kreienbrock, M Kreuzer, F Lagarde, I Mäkeläinen, C Muirhead, W Oberaigner, G Pershagen, A Ruano-Ravina, E Ruosteenoja, A Schaffrath Rosario, M Tirmarche, L Tomácek, E Whitley, H-E Wichmann, and R Doll
British Medical Journal 330: 223, Jan 2005
7,148 Cases, 14,208 controls
Residential Radon and Risk of Lung Cancer: a Combined Analysis of 7 North American Case-control Studies
Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS,Field RW,Klotz JB, Letourneau EG, Lynch CF, Lyon JI,Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB
Epidemiology 16(2):137-45. Mar 2005
3,662 cases, 4,966 controls
Basement and Living Area Radon Concentrations for U.S. Residential Radon Studies.
1Summary data represent those homes that were measured with no imputed (values added to replace missing values) values.
10% – 18%
New Jersey, Missouri I, Canada, Iowa, Missouri II, a combined study from Connecticut, Utah and S. Idaho
Shenyang, China, Stockholm, Sweden, Swedish nationwide, Winnipeg, Canada, S. Finland, Finnish nationwide, SW England, W. Germany, Sweden, Czech Republic, Italy-Trento, Spain, Austria, France, China - Gansu Province, E. Germany
Therefore, estimated pooled risk estimates are likely low.
Journal of Exposure Analysis and Environmental Epidemiology 12(3):197-203, 2002.
0.8Risk Estimates for Alternative Models(live cases and controls)
Other location radon concentrations only
JEAEE 12(3): 197-203, 2002
February 2006 issue
Samet, J. Residential Radon Epidemiology
Zielinski, J, Field, R.W., Residential Radon and Lung Cancer - Preface
Krewski et al. A Combined Analysis of North American Case-Control Studies of Residential Radon and Lung Cancer.
Field et al. An Overview of the North American Case-Control Studies of Residential Radon and Lung Cancer.
Sandler et al. Connecticut, Utah/S. Idaho Residential Radon Studies
Steck, D., Field, R.W. Dosimetric Challenges for Residential Radon Epidemiology.
Led by Sarah Darby at Oxford, U.K.
Next meeting of investigators – Geneva, March 2006
Anticipated completion 2007
New Jersey, Missouri I, Canada, Iowa, Missouri II, Connecticut, Utah and S. Idaho, Shenyang, China, Stockholm, Sweden, Swedish nationwide, Winnipeg, Canada, S. Finland, Finnish nationwide, SW England, W. Germany, Sweden, Czech Republic, Italy-Trento, Spain, Austria, France, China - Gansu Province, E. Germany
10,810 cases; 19,174 controls
Current collaboration between the University of Iowa and the National Cancer Institute involve pooling of the glass-based retrospective radon detectors used in the two studies. We believe the glass-based detectors provide both improved retrospective radon and radon progeny dosimetry.
Glass-based detectors measure embedded radon progeny in glass surfaces and can be used to reconstruct the average radon concentration for periods as long as several decades.
4 dayRetrospective Radon Detectors
Dose per unit radon
Exposure room studies
Comparison with exposure room results
Genetic polymorphisms are defined as variations in
DNA that are observed in 1% or more of the population.
indirectly damage DNA
Free radical formation
Double –strand DNA breaks
Defects in tumor suppressor genes – p53
At risk individuals–GSTM1
(glutathione S-transferase M1)
Bonner MR, Bennett WP, Lan Q,Wright ME, Lubin JH, Field RW, Brownson RC, Alavanja MCR,Radon, Environmental Tobacco Smoke, Glutathione-s-transferase M1 and Lung Cancer in US Women.
us to think about it
“Motivation is a fire from within. If someone else tries to light that fire under you, chances are it will burn very briefly.”
Stephen R. Covey
Lung Cancer (radon)
Annual U.S. Cancer Deaths
Develop guidelines for member countries to reduce radon exposure and develop radon measurement and mitigation guidelines.