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Mouse Double Minute 2 (MDM2)

Mouse Double Minute 2 (MDM2). Kirubel Asfaw. MDM2 Discovery. Momand et al. MDM2 inhibits p53. p53.free.fr. p53 Cellular Functions. Master control of cell cycle It is a transcription factor. Responds to cellular stresses by activating growth arrest or apoptosis.

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Mouse Double Minute 2 (MDM2)

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  1. Mouse Double Minute 2 (MDM2) Kirubel Asfaw

  2. MDM2 Discovery Momand et al

  3. MDM2 inhibits p53 p53.free.fr

  4. p53 Cellular Functions • Master control of cell cycle • It is a transcription factor. • Responds to cellular stresses by activating growth arrest or apoptosis

  5. Mechanisms of Inhibition p53.free.fr

  6. Phosphorylation activates p53 p53.free.fr

  7. MDM2 cellular functions in normal cells • Cell survival • Cell cycle progression

  8. MDM2’s ability to control p53 is essential during development p53.free.fr Jones et al

  9. MDM2 is an oncogene • MDM2 overexpression blocks p53-mediated cell-cycle arrest and apoptosis.

  10. MDM2 protein overexpression due to SNPs

  11. Analysis of 3000 tumor samples shows that MDM2 is amplified in 7% of these tissues. Momand et al

  12. MDM2 protein overexpression due to gene amplification Wikepedia.org

  13. SNP309 polymorphism was detected in 232 (68%) of 343 familial breast cancer cases Wasielewski et all

  14. No MDM2 gene amplification was observed in the presence of mutated p53 gene Pollock et al

  15. The p53-MDM2 interface is a target for cancer therapy

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