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Hematopoietic Stem Cells. Multipotent Hematopoietic Stem Cell- A stem cell that differentiates into any of the blood cells . Used most. Multipotent vs. Pluripotent Which is better?. What are hematopoietic stem cells made of?. Lymphocyte-biased HSC’s (Ly-bi)

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hematopoietic stem cells
Hematopoietic Stem Cells
  • Multipotent
  • Hematopoietic Stem Cell- A stem cell that differentiates into any of the blood cells.
  • Used most.
slide4

Lymphocyte-biased HSC’s (Ly-bi)

  • High L/M ratio. Lymphocytes >10.
  • 2. Myeloid-biased HSC’s (
  • 3. Balanced HSC’s (Bala)
  • Lymphocytes > or = 3 and < or = 10
bone marrow
Bone Marrow
  • Where is it found most?
  • Extraction
  • How is it Maintained?
  • First Bone Marrow Transplant
peripheral blood
Peripheral Blood
  • Hormone Growth Factors.
  • How are they extracted?
  • Peripheral Blood Machine
  • How are they maintained?
umbilical cord blood
Umbilical Cord Blood
  • Percentage, first transplant.
  • Where?
  • Benefit
which source is best
Which Source is Best?
  • Bone Marrow Pros
  • Bone Marrow Cons
  • Peripheral Blood Pros
  • Peripheral Blood Cons
  • Umbilical Cord Blood Pros
  • Umbilical Cord Blood Cons
leukemia
Leukemia
  • Disease of White blood cells
  • Results when cells function abnormally
  • Interfere with other organs
  • Five stages of severity
  • Two main types, chronic and acute.
  • Why are hematopoietic Stem cells used as opposed to another type?
curing leukemia via stem cell transplant
Curing Leukemia via Stem Cell Transplant
  • 1. Need a perfect donor
  • 2. Destroy Immune System by chemotherapy and radiation.
  • 3. Stem cell transplant from one of the three sources.
  • The hematopoietic stem cells start making new blood cells and fix the immune system.
  • Make a complete new one without abnormal cells.