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DA dendrite formation

This research explores the intricate mechanisms underlying dendrite formation and guidance in the context of axonal and dendritic growth. We investigate the role of guidance molecules such as Robo3 and their influence on the development of sensory organs and associated neurons. The study also examines the genetic pathways regulating these processes, including the impact of mutations on dendritic routing defects and the competitive interactions between dorsal groups of neurons. These insights contribute to our understanding of neuronal architecture and its implications in neuroscience.

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DA dendrite formation

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  1. DA dendrite formation

  2. Dendrite guidance

  3. Clock model: axonal and dendritic growth are internally regulated, depending on how to respond to guidance molecules

  4. Robo3 over-expression in TTMn Robo3 over-expression in both GF & TTMn WT GF, giant fiber interneuron TTMn: tergotrochantral motor neuron

  5. Neuropil model: same guidance molecules for attracting (or including) axon and dendrite together for synapse TRENDS in Neurosciences Vol.27 No.4 April 2004

  6. Sensory organs Proneural genes + associated MD neurons achaete scute + associated MD neurons atonal solo-MD neurons amos

  7. ES MD/ mono-ES MD/ poly-ES ASC ASC ASC solo-MD CH MD/ CH ato ato amos ES CH amos MD Brewster and Bodmer, 1995

  8. hamlet, a binary switch gene for MD/ES neuron determination

  9. Control of dendrite development Luo. et al. Trends Neuroscience (2003)

  10. DA Dendrite formation

  11. pros mutations causes routing defect Constitutive active CDC42 induce supernumerary primary dendrites that fail to extend dorsally and grow secondary dendrites WT CDC42

  12. Lateral branch defects: (A) WT, (B) reduced, (C) fail to extend, (E, F) over shrinking Increased density

  13. Sequotia (水杉), Zn finger protein

  14. No invasion into ablated region in dorsal region in third instar No repulsion in dorsal group

  15. Competition between two dorsal groups of contralateral dorsal groups

  16. Dorsal dendrite overextension in flamingo mutants

  17. Class II Class I

  18. Class III

  19. Tiling of dendrites within the same class of DA neurons Development (2002) Grueber et al

  20. Cell (2003) Grueber et al

  21. Dendrites of different classes overlap extensively

  22. Class IV tiling

  23. Differential Cut levels in four types of DA neurons

  24. cut mutant phenotypes in class III

  25. Class II Class I

  26. Class I Class II

  27. Class IV No effect on class III

  28. Dendrites over-branching and over-lapping phenotypes

  29. Defect in like-dendrite avoidance response WT fry

  30. Heteroneuronal tiling defect Fry Trc kinase tiling Rac branching

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