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Istologia Corso di Laurea in Medicina e Chirurgia - A.A. 2002-03
Lezione 6 18 Marzo 2003
Proprietà n. 4: Immortalità replicativa Le cellule staminali
APC inactivation simulates the presence of a constitutive Wnt signaling
APC or -catenin mutation: stem cell- like phenotype Differentiated, non-proliferating cells -catenin/TCF OFF Epithelial stem cells (proliferating) -catenin/TCF ON -catenin/TCF target gene expression domain Van de Wetering et al., 2002