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BASKET-PROVE

The BASKET-PROVE trial aimed to compare the clinical efficacy of first-generation sirolimus-eluting stents (SES), bare metal stents (BMS), and second-generation everolimus-eluting stents in patients with coronary lesions in large arteries (≥3 mm). This multicenter, single-blind randomized trial included 2314 participants, assessing the composite endpoint of cardiac death or myocardial infarction at 24 months. Results indicated no significant differences in death or MI rates among the stent types, with drug-eluting stents linked to a reduced need for target vessel revascularization.

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BASKET-PROVE

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  1. BASKET-PROVE Objective:To compare clinical efficacy of first generation SES implantation, 1st generation BMS and 2nd generation everolimuseluting stents in patients with coronary lesions in large coronary arteries (≥ 3 mm). Study: Multicenter, single blind randomized trial. Population: All comers (STEMI, NSTEMI, UA, stable angina) with de novo native coronary lesions ≥ 3 mm. No shock, no LM. Endpoint: Composite of cardiac death or MI at 24 months f-up.

  2. BASKET-PROVE Enrolled n=2314 SES (Cypher) n=775 Everolimuseluting Stents (Xience V) n=774 BMS (Vision) n=765

  3. BASKET-PROVE Event rate at 24 months % P=0.007 NS NS NS NS P=0.002

  4. BASKET-PROVE Conclusion: In patients requiring stenting of large coronary arteries no difference between the rate of death or MI were found between sirolimus eluting, everolimuseluting and bare metal stents. Drug eluting stent implantation resulted in a decreased TVR. Kaiser et al. N Engl J Med 2010;363:2310-2319

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