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Peroxisomes

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  1. Peroxisomes Haley Nathanson

  2. What are peroxisomes? • Peroxisomes are membrane-bound organelles found in the cytoplasm of eukaryotic cells. • Peroxisomes contain enzymes that oxidize fatty acids and amino acids. Stained human peroxisome 

  3. Anatomy of peroxisomes

  4. Function • Peroxisomes are responsible for protecting the cell from the production of hydrogen peroxide. • Peroxisomes contain an oxidation enzyme, known as catalase. • Catalase breaks down the hydrogen peroxide to form one oxygen molecule and two water molecules.

  5. Breakdown ofhydrogen peroxide • 2H2O2 → 2H2O + O2 hydrogen catalase 2 water 1 oxygen peroxide molecules molecule

  6. Peroxisome Biogenesis disorders • Zellweger Syndrome (ZS) • Most Severe • Neonatal Adrenoleukodystrophy (NALD) • Infantile Refsum Disease (IRD) • Least Severe All of these disorders are caused by defective peroxisomes.

  7. Zellweger Syndrome (ZS) Facial features of a child with ZS

  8. Neonatal Adrenoleukodystrophy (NALD)

  9. Infantile Refsum Disease (IRD)

  10. Works cited • "Neonatal Adrenoleukodystrophy." Penn Medicine. The University of Pennsylvania Health System,, 1 Dec. 2001. Web. 14 Mar. 2014. <http://www.pennmedicine.org/encyclopedia/em_DisplayImage.aspx?gcid=17277&ptid=2>. • "INFANTILE REFSUM DISEASE." — Windows Of Hope. St. George's, University of London and University of Arizona, n.d. Web. 14 Mar. 2014. <http://www.wohproject.org/Disorders/a-z/infantile-refsum-disease-1/infantile-refsum-disease>. • "NINDS Infantile Refsum Disease Information Page." Infantile Refsum Disease Information Page: National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 14 Mar. 2014. <http://www.ninds.nih.gov/disorders/refsum • "Diseases &amp Conditions." <i>Cleveland Clinic</i>. Cleveland Clinic, n.d. Web. 14 Mar. 2014. &lt;http://my.clevelandclinic.org/disorders/adrenoleukodystrophy/hic_what_is_adrenoleukodystrophy.aspx&gt;. • "Zellweger Syndrome." Indian Pediatrics - Editorial. Indian Pediatrics, n.d. Web. 14 Mar. 2014. <http://www.indianpediatrics.net/july2003/july-682.htm>.

  11. Works Cited (Continued) • "Peroxisomes." Molecular Expressions Cell Biology: Animal Cell Structure - Peroxisomes. Michael Davidson and The Florida State University, 10 May 2005. Web. 15 Mar. 2014. <http://micro.magnet.fsu.edu/cells/peroxisomes/peroxisomes.html>. • Cooper, John. "peroxisome (biology)." <i>Encyclopedia Britannica Online</i>. Encyclopedia Britannica, 12 June 2013. Web. 14 Mar. 2014. &lt;http://www.britannica.com/EBchecked/topic/452457/peroxisome&gt;. • "The Human Protein Atlas." Vesicles (Peroxisomes). The Human Protein Atlas, n.d. Web. 14 Mar. 2014. <http://www.proteinatlas.org/dictionary/cell/vesicles+(peroxisome)+2>.