Catalytic Mechanism of Chymotrypsin slide 1. Chymotrypsin Protease: catalyze hydrolysis of proteins in small intestine Specificity: Peptide bond on carboxyl side of aromatic side chains (Y, W, F) & Large hydrophobic residues (Met,…). Three polypeptide chains cross-linked to each other
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Deacylation (rate limiting; reverse of acylation with water substituting the amine component)
A tightly bound Zn2+
Essential for catalysis
Coordinated to 1H2O, 2 His, 1 Glu