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VUOS

COMPANY PROFILE PARTNER FOR COOPERATION. VUOS. Where you can find us. 2. VUOS – PARTNER FOR COOPERATION. VUOS ownership. SYNTHESIA, a.s. VUOS, a.s. AGROFERT HOLDING, a.s. 100 %. 100 %. 3. VUOS – PARTNER FOR COOPERATION. History. 100% daughter company of Synthesia a.s.

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VUOS

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  1. COMPANY PROFILE PARTNER FOR COOPERATION VUOS

  2. Where you can find us • 2 • VUOS – PARTNER FOR COOPERATION

  3. VUOS ownership • SYNTHESIA, a.s. • VUOS, a.s. • AGROFERT • HOLDING, a.s. • 100% • 100% • 3 • VUOS – PARTNER FOR COOPERATION

  4. History • 100% daughter company of Synthesia a.s. • Foundation of Research Laboratories • Affiliation of Synthesia´s R&D • Voucher Privatisation • New name – VUOS • 1941 • 1997 • 2004 • 1952 • 1992 • 4 • VUOS – PARTNER FOR COOPERATION

  5. VUOS main businesses • 1. R&D and Production of Fine Chemicals • 2. Toxicology and Analytics • 6 • 10 • 14 • 70 • Employees • Sales in % • 5 • VUOS – PARTNER FOR COOPERATION

  6. The Certificates of VUOS • Certificate ČSN EN ISO 9001: 2009  (organic chemicals - syntheses development and manufacture) • Certificate of Good Manufacturing Practice (GMP) • Certificates of Good Laboratory Practice in Test Facility (OECD GLP Principles - 1997) • Certificate of Accredited Certification Body for Certification of Products (EN 45011:1998) • Certificate of Accredited Testing Laboratory (EN ISO/IEC 17025:2005) • 6 • VUOS – PARTNER FOR COOPERATION

  7. Strong Points • Educationstructureofemployees • VUOS is located in area of long-lastingchemical tradition andcomplete infrastructure • Cooperation with University of Pardubice • Skilled – 25 % • Secondary – 30% • University degree – 36% • Ph.D. degree – 9% • 7 • VUOS – PARTNER FOR COOPERATION

  8. R&D, upscaling • • Pharmaceutical intermediates • also under GMP standard • • Intermediates for microelectronics • • Custom syntheses of chemical specialities • • Dyes and pigments for special application • 8 • VUOS – PARTNER FOR COOPERATION

  9. R&D, upscaling • Wide range of quantities • Grams – in laboratory • Kilograms – in kilolab unit • Metric tons – in VUOS • production plant • Hundreds of MT – • 9 • VUOS – PARTNER FOR COOPERATION

  10. VUOS key chemistry • Adamantane derivatives • N-Heterocycles • API Building Blocks • VUOS ’s key technology • Hydrogenation • Phosgenation • 10 • VUOS – PARTNER FOR COOPERATION

  11. VUOS technology/manufacture expertiseincludes: • Organometallic and Cryogenic Chemistry • Organolithium Chemistry • Organozinc Chemistry • Grignards • Sodium Hydride Reactions • Transition-Metal Catalysis • Homogeneous and Heterogeneous Transition-Metal Catalysis • Cross Couplings (Suzuki, Kumada, Heck, etc.) • Hazardous and Unpleasant Chemistry • Phosgenation • Halogenation (PCl3, POCl3, SOCl2, BCl3, BBr3, etc.) • Rections with Nitroalkanes • Nitration • Sulfonation • Reduction and High-Pressure Hydrogenations • Reduction with Sodium borohydride, Red-Al, Superhydride, etc. • Reductive Alkylation • Reductive Amination • Hydrogenolysis • Dehalogenation • 11 • VUOS – PARTNER FOR COOPERATION

  12. Kilolab and Production Unit • Phosgenation • Reactors up to 1 600 l • 2x High performance rectification columns • Laboratory phosgenation units from 1 to 30 l • 12 • VUOS – PARTNER FOR COOPERATION

  13. Kilolab and Semi-Pilot Unit • Hydrogenation • 3x autoclaves 100 l each, 60, 120 and 130bar, up to 200 ˚C, Hastelloy C clad • 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad • 1x autoclave 700 l, 100 bar, 200 ˚C, stainless steel • 1x autoclave 1 000 l, 10 bar, 140 ˚C, stainlesssteel • many small autoclaves up to 10 l • 13 • VUOS – PARTNER FOR COOPERATION

  14. Kilolab and Production Unit • Low temperature, RLi, RMgX, NaH • Reactors up to 630 l cooled down to – 80 ˚C • 1x glass-lined reactor for NaH reactions (250 l) • 3x glass reactors 100l cooled down to – 40°C • 14 • VUOS – PARTNER FOR COOPERATION

  15. Kilolab and Semi-Pilot Unit • Multipurpose chemistry • 20x glass reactors, 100 l each • 6x glass lined reactors (200–1 500 l) • 2x evaporators 50 l / h • 4x stainless steel reactors (300–1 500 l) sufficient filtration and distillation capacity • 15 • VUOS – PARTNER FOR COOPERATION

  16. GMPProduction Line • Production of API, advanced intermediates, • controlled finalization • Glass-lined vessels 400 and 630 l • Stainless steel vessels 400 and 630 l • Filtration, Centrifuging and Drying • 16 • VUOS – PARTNER FOR COOPERATION

  17. Production Unit • Production Equipment • 52x glass lined reactors, total vol. 85 000 l (500 – 6 000 l) • 16x stainless steel reactors, total vol. 29 000 l (1 000–6 000 l) • 8x High performance rectification columns • sufficient filtration capacity (nutsches, centrifuges) • computer controlled • 17 • VUOS – PARTNER FOR COOPERATION

  18. New Production Unit dedicated for production of Pharma Intermediates • Purpose • Dedicated for the production of pharma intermediates under GMP standard • 5 reactors , total volume 10 000 l, stainless steel and glasslined • Filtration, distillation, drying • Supposed to be ready in the year 2018 • Investment cost 4 mil. EUR • 18 • VUOS – PARTNER FOR COOPERATION

  19. New Unit dedicated for grinding, drying and blending of dry materials • Purpose • Dedicated for the for grinding, blending and drying of pharma intermediates under GMP standard • 3 tray dryers in separate rooms with separate ventilation • Equipment for grinding and blending • Investment cost 1 mil. EUR • 19 • VUOS – PARTNER FOR COOPERATION

  20. Toxicology, Ecotoxicology and Analytics • 20 • VUOS – PARTNER FOR COOPERATION

  21. Toxicology, Ecotoxicology and Analytics • REACH and CLP Services • Literaturesearch • Preparationofdossiers in IUCLID 5 • PreparationofChemicalSafety Report • Non-testingapproaches • (Q)SAR • Grouping/Read-across • Preparationof SDS • Classificationofsubstances and mixtures • 21 • VUOS – PARTNER FOR COOPERATION

  22. Toxicology, Ecotoxicology and Analytics • Analyticalmethods • NMR Spectrometry • MassSpectrometry (LC/GC-MS) • ICP-AES • IR Spectrometry • Chromatography (HPLC, GC) • UV-VIS • 22 • VUOS – PARTNER FOR COOPERATION

  23. Toxicology, Ecotoxicology and Analytics • Toxicologicaltests • In vivo and in vitro testsaccording • to the OECD or EU methods: • Acute toxicity • Skin and Eyeirritation • Sensibilisation • Repeated dose toxicity • Reproductive toxicity • Carcinogenicity • Mutagenicity • 23 • VUOS – PARTNER FOR COOPERATION

  24. Toxicology, Ecotoxicology and Analytics • Ecotoxicologicaltests • Aquatic toxicity • Bioticdegradation • Abioticdegradation • Adsorption/desorption • Physico-chemicaltests • Information on physicochemicalpropertiesof substance • 24 • VUOS – PARTNER FOR COOPERATION

  25. Contacts • General Manager: Dr. Karel Novák • Phone: +420 46 682 2550 • e-mail: karel.novak@vuos.com • Sales Manager: Miloš Jesenský,Ph.D. • Phone: +420 46 682 3300 • e-mail: milos.jesensky@vuos.com • R&D: Pavel Holý, Ph.D. • Phone:+420 46 682 3156 • e-mail: pavel.holy@vuos.com • Analytics: Michal Bartoš • Phone:+420 46 682 2501 • e-mail: michal.bartos@vuos.com • Toxicology • Phone:+420 724 400 557 • e-mail: petra.plodikova@vuos.com • 25 • VUOS – PARTNER FOR COOPERATION

  26. Výzkumný ústav organických syntéz a.s. • Rybitví č.p. 296, 533 54 Rybitví, Czech Republic • www.vuos.com

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