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Some are hermaphrodites They can fertilize their first batch of eggs internally

Roundworms. Some are hermaphrodites They can fertilize their first batch of eggs internally. RAS gene (mutant) mutant hermaphrodite fail to develop a vulva. After self-fertilizing their eggs, they have no way of laying them Eggs hatch inside the bodies and

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Some are hermaphrodites They can fertilize their first batch of eggs internally

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  1. Roundworms • Some are hermaphrodites • They can fertilize their first batch of • eggs internally

  2. RAS gene (mutant) • mutant hermaphrodite • fail to develop a vulva

  3. After self-fertilizing their eggs, • they have no way of laying them • Eggs hatch inside the bodies and • the larvae devour their mothers

  4. Human RAS gene (normal) • involved in cell division • Human RAS gene (mutations) • associated with cancers of the • colon, liver, lungs, and bladder Associated with Costello Syndrome

  5. When a male encounters a hermaphrodite • Locates the vulva • Deposits sperms

  6. lov-1 gene • involved in mating behavior • allows males to locate the females vulva • Mutant lov-1 gene • males don’t notice the vulva

  7. lov-1 • matches the human PKD1 gene PKD1 (normal) codes for a Ca channel protein

  8. PKD1 (mutant) involved in polycystic kidney disease (cysts in the kidneys) affects > 12 million people worldwide

  9. Key Points Our genes come from pre-existing genes Some of these genes have the same function as in other organisms Some of these genes have completely different function

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