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NIH Challenge Grants in Health and Science Research

NIH Challenge Grants in Health and Science Research . RFA OD-09-003. Background. New funds to NIH for 2009 and 2010 as part of the ARRA Challenge areas should have a high impact

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NIH Challenge Grants in Health and Science Research

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  1. NIH Challenge Grants in Health and Science Research RFA OD-09-003

  2. Background • New funds to NIH for 2009 and 2010 as part of the ARRA • Challenge areas should have a high impact • Novel research that addresses knowledge gaps, opportunities, new technologies, data generation, or research methods

  3. Nuts and Bolts • Deadline is April 27, to DEH by April 13th! • Non-modular budget up to $500,000 / year total cost for two years • Earliest start date 9/30/09 • Research plan is limited to 12 pages • NO resubmissions

  4. Useful websites • http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-09-003.html • http://grants.nih.gov/recovery/faqs_challenge.html

  5. Useful (?) websites • http://grants.nih.gov/grants/funding/challenge_award/Omnibus.pdf --a 181 page document • http://www.niehs.nih.gov/recovery/challengegrants.cfm --NIEHS Challenge topics • http://grants.nih.gov/grants/funding/challenge_award/IC_ChallengeWebPage.htm --all institutes

  6. Review Criteria • The new (2010) criteria will be used for Recovery Act FOAs. • http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-025.html • For comparison of current and new criteria • http://grants.nih.gov/grants/peer/side_by_side_comparison.doc

  7. Grant preparation • Project summary / abstract • Bibliography and references – 1 page • Biosketch – 2 pages.Limit publications to TEN (10) • Specific Aims – 1 page • Research plan—12 pages

  8. Additional sections • Inclusion Enrollment Report • Protection of Human Subjects • Inclusion of Women and Minorities • Targeted/Planned Enrollment • Inclusion of Children • Vertebrate Animals • Select Agent Research • MPI Leadership Plan • Consortium/ Contractual Arrangements • Letters of Support • Resource Sharing Plans – Data Sharing Plan, Sharing Model Organisms, and Genome-Wide Association Studies

  9. Research Plan • Research area and project title • The challenge and potential impact • Approach • Timeline and milestones

  10. The Challenge / Potential Impact • What is the research opportunity, scientific knowledge gap or technology that will be addressed? • How broad is the potential impact in science and/or health?

  11. The Challenge / Potential Impact • Which community will be affected? • What is the size of the community? • Will the potential impact be major?

  12. The Challenge / Potential Impact • What is the disease or condition that will be studied ? • What is the hypothesis to be tested concerning mechanisms underlying this disease/condition?

  13. The Challenge / Potential Impact • How will the work disrupt the standard paradigm or create a paradigm where none exists? • How will the results transform our understanding of this disease/condition?

  14. The Approach • Provide enough information that reviewers • can determine what, in general, you are • proposing to do, but do not include a detailed • experimental plan.

  15. The Approach • If your methodology is novel, what is unconventional and exceptionally innovative about your approach? • How does your approach differ from what other investigators have attempted to do?

  16. Timeline and Milestones • Why is the proposed research uniquely • suited to the stated goals of the challenge • initiative? • What is the likelihood of success? • Provide a timeline for the proposed research. • To facilitate evaluation of progress reports, • describe when you anticipate that essential • components of the project will be completed.

  17. New Scoring System • 9-point scale (1 = exceptional; 9 = poor) • Before review meeting, reviewers and discussant will give a 1 – 9 for each area: • Significance • Investigator(s) • Innovation • Approach • Environment You will receive the scores for these criteria, even if your grant is “triaged”

  18. New Scoring System (cont) • Priority Scores: Before the review meeting, each reviewer and discussant will give a preliminary impact score for that application. • This score is evaluation of the overall impact, rather than a weighted average to previous review criteria.

  19. Other ARRA Concepts • Comparative Effectiveness Research (CER) • Role of trials versus observational studies • Establishing priorities • Optimally using existing resources • Coordinating federal agencies and other research collaborators • Improving research methods • What’s the importance of cost? • Public-Private Partnerships http://ppp.od.nih.gov/

  20. Caveats! No plan survives contact with the enemy “High achievement always takes place in the framework of high expectation.” –Charles Kettering

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