Topirol Tablets (Generic Topiramate Tablets)

1. Topirol Tablets (Generic Topiramate Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Topirol Tablets (Generic Topiramate Tablets) Topirol (Generic Topiramate Tablets) is used alone or with other medicines to prevent and control seizures (epilepsy). Topirol is used alone in adults, adolescents and children over 6 years of age with partial seizures with or without secondary generalised seizures, and primary generalised tonic-clonic seizures. This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used as an adjunctive therapy in children aged 2 years and above, adolescents and adults with partial onset seizures with or without secondary generalization or primary generalized tonic-clonic seizures and for the treatment of seizures associated with Lennox- Gastaut syndrome. Topiramate tablets is used in adults for the preventive treatment of migraine headache in patients 12 years of age and older after careful evaluation of possible alternative treatment options. Topiramate tablets not used for acute treatment of Migraine. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Topirol Tablets (Generic Topiramate Tablets) Active Ingredient The active ingredient present in Topirol is Topiramate. Each Topirol tablet contains 25 mg, 50 mg or 100 mg of Topiramate. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Topirol Tablets (Generic Topiramate Tablets) Chemical Structure The structure of Topiramate is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Topirol Tablets (Generic Topiramate Tablets) Topirol Tablets are manufactured by Sun Pharmaceutical Industries Limited, India in the strengths of 25 mg, 50 mg and 100 mg. ( Website: https://sunpharma.com/ https://sunpharma.com/ ) URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Topirol Tablets (Generic Topiramate Tablets) Topiramate Tablets – Brand Names Topiramate tablets are available under various Drug trade names that include Topirol from Sun, Nextop from Torrent, Topamac from J & J (Janssen), Topamate from Cipla, Topaz from Intas, Topex from Cipla, Topirain from Unichem, Topiram from Zydus, Toprisun from Sunrise. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Topirol Tablets (Generic Topiramate Tablets) Uses of Topirol 25 mg, 50 mg and 100 mg Tablets Topirol tablets (Topiramate tablets) is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Topirol Tablets (Generic Topiramate Tablets) Topirol Tablets Dosage Topirol tablets (Generic Topiramate Tablets) is The dosage of Topirol tablets given below: Epilepsy Monotherapy: Epilepsy Monotherapy: Adults and Pediatric patients more than 10 years: The initial dosage is 50 mg/day in two divided doses. The dosage should be increased weekly by increments of 50 mg for the first 4 weeks then 100 mg for weeks 5 to 6. The recommended dosage is 400 mg/day in two divided doses. Epilepsy Adjunctive Therapy: Epilepsy Adjunctive Therapy: Adults with partial onset seizures or LGS. The initial dosage is 25 to 50 mg/day. The dosage should be increased weekly to an effective dose by increments of 25 to 50 mg. The recommended dosage is 200 mg to 400 mg/day in two divided doses. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Topirol Tablets (Generic Topiramate Tablets) Topirol Tablets Dosage Topirol tablets (Generic Topiramate Tablets) is The dosage of Topirol tablets given below: Epilepsy adjunctive therapy: Epilepsy adjunctive therapy: Adults with primary generalized tonic- clonic seizures. The initial dosage is 25 to 50 mg/day. The dosage should be increased weekly to an effective dose by increments of 25 mg to 50 mg. The recommended dosage is 400 mg/day in two divided doses. Prophylaxis of Migraine: Prophylaxis of Migraine: The initial dosage is 25 mg/day administered nightly for the first week. The dosage should be increased weekly by increments of 25 mg. Dose and titration should be guided by clinical outcome. The recommended dosage is 100 mg/day administered in two divided doses. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Topirol Tablets (Generic Topiramate Tablets) Contraindications Topirol tablets are contraindicated in patients with a hypersensitivity to Topiramate or any other component of this medication. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Topirol Tablets (Generic Topiramate Tablets) Storage Instructions Topirol Tablets (Generic Topiramate Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Topirol Tablets (Generic Topiramate Tablets) Warnings Acute myopia and secondary angle closure glaucoma: can lead to permanent visual loss; discontinue topiramate as soon as possible Visual field defects: consider discontinuation of Topiramate Oligohidrosis and hyperthermia: monitor decreased sweating and increased body temperature, especially in pediatric patients Metabolic acidosis: baseline and periodic measurement of serum bicarbonate is recommended; consider dose reduction or discontinuation of Topiramate if clinically appropriate. Suicidal behavior and ideation: antiepileptic drugs increase the risk of suicidal behavior or ideation Cognitive/neuropsychiatric adverse reactions: use caution when operating machinery including cars; depression and mood problems may occur. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Topirol Tablets (Generic Topiramate Tablets) Warnings Fetal Toxicity: use during pregnancy can cause major congenital malformations, including but not limited to cleft lip and/or palate, and being small for gestational age Withdrawal of AEDs: withdraw Topiramate gradually Decrease in Bone Mineral Density: has been shown to decrease bone mineral density and bone mineral content in pediatric patients Negative effects on growth (height and weight): may slow height increase and weight gain; carefully monitor children receiving prolonged therapy Serious skin reactions: If SJS or TEN is suspected, discontinue topiramate Hyperammonemia/encephalopathy: measure ammonia if encephalopathic symptoms occur Kidney stones: avoid use with other carbonic anhydrase inhibitors, drugs causing metabolic acidosis, or in patients on a ketogenic diet Hypothermia has been reported with and without hyperammonemia during Topiramate treatment with concomitant valproic acid use © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Topirol Tablets (Generic Topiramate Tablets) Side Effects The most common Topiramate (Topirol Tablets) side effects with an incidence rate of 10% more frequent than placebo at recommended dosing in adult and pediatric controlled, epilepsy clinical trials were paresthesia, anorexia, weight decrease, speech disorder related speech problem, fatigue, dizziness, somnolence, nervousness, psychomotor slowing, abnormal vision and fever. The most common Topiramate side effects with an incidence rate of 5% more frequent than placebo at recommended dosing in adult and adolescent controlled, migraine clinical trials were paresthesia, anorexia, weight decrease, difficulty with memory, taste perversion, upper respiratory tract infection, abdominal pain, diarrhea, hypoesthesia, and nausea. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Topirol Tablets (Generic Topiramate Tablets) Overdose Overdoses of Topiramate (Topirol tablets) have been reported. Signs and symptoms included convulsions, drowsiness, speech disturbance, blurred vision, diplopia, mentation impaired, lethargy, abnormal coordination, stupor, hypotension, abdominal pain, agitation, dizziness and depression. The clinical consequences were not severe in most cases, but deaths have been reported after poly-drug overdoses involving Topiramate. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Topirol Tablets (Generic Topiramate Tablets) Overdose In acute Topiramate (Topirol tablets) overdose, if the ingestion is recent, the stomach should be emptied immediately by lavage or by induction of emesis. Activated charcoal has been shown to adsorb Topiramate in vitro. Treatment should be appropriately supportive. Hemodialysis is an effective means of removing topiramate from the body. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Topirol Tablets (Generic Topiramate Tablets) Topirol Tablets During Pregnancy Topiramate (Topirol tablets) has been classified by the US FDA as Pregnancy Category D. If you take Topiramate tablets during pregnancy, your baby has a higher risk for birth defects called cleft lip and cleft palate. These defects can begin early in pregnancy, even before you know you are pregnant. Data from pregnancy registries indicate that infants exposed to Topiramate (Topirol tablets) in utero have an increased risk of major congenital malformations, including but not limited to cleft lip and/or cleft palate (oral clefts), and of being small for gestational age (SGA). Topiramate should be used during pregnancy only if the potential benefit outweighs the potential risk. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Topirol Tablets (Generic Topiramate Tablets) For more details on Topirol Tablets click here Topirol Tablets (Topiramate Tablets) by Sun Pharmaceutical Industries Limited, India. URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html URL: https://www.clearskypharmacy.biz/generic-topamax-topirol-by-sun-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )