Lametec DT Tablets (Generic Lamotrigine Tablets)

1. Lametec DT Tablets (Generic Lamotrigine Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT (Generic Lamotrigine Tablets) is used as adjunctive therapy for the following seizure types in patients 2 years of age or greater: partial seizures, primary generalized tonic-clonic seizures and generalized seizures of Lennox- Gastaut syndrome. Lametec DT tablets are also used for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults 18 years of age or greater treated for acute mood episodes with standard therapy. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Lametec DT Tablets (Generic Lamotrigine Tablets) Active Ingredient The active ingredient present in Lametec DT tablets is Lamotrigine. Each dispersible uncoated Lametec DT tablet contains 5 mg, 25 mg, 50 mg or 100 mg of Lamotrigine in a flavoured base. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Lametec DT Tablets (Generic Lamotrigine Tablets) Chemical Structure The structure of Lamotrigine is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT Tablets are manufactured by Cipla Limited, India in the strengths of 5 mg, 25 mg, 50 mg and 100 mg. ( Website: https://www.cipla.com/ https://www.cipla.com/ ) URL: URL: https://www.clearskypharmacy.biz/generic-lamictal-lametec-by-cipla.html https://www.clearskypharmacy.biz/generic-lamictal-lametec-by-cipla.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Lametec DT Tablets (Generic Lamotrigine Tablets) Lamotrigine Tablets – Brand Names Lamotrigine tablets are available under various brand names such as Lamictal, Lametec, Lametec-DT , Lametec, Lamepil, Lamictin, Lamez, Lamosyn, Favlam, Lamorig, Lamitor-DT, Lamitor- OD and Lamidus. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Lametec DT Tablets (Generic Lamotrigine Tablets) Uses of Lametec DT 5 mg, 25 mg, 50 mg and 100 mg Tablets Lametec DT (Generic Lamotrigine Tablets) is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. It can also be used in the treatment of bipolar disorder (manic-depressive illness) in adults. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT Tablets Dosage The dosage of Lametec DT tablets Lametec DT tablets (Lamotrigine Tablets) is given below: Dosage for Treatment of Epilepsy Add-On Therapy In Adults (over 12 years of age) In patients taking valproate with/without any other anti-epileptic drug (AED), the initial Lametec DT (Lamotrigine Tablets) dose is 25 mg every alternate day for two weeks, followed by 25 mg once a day for two weeks. Thereafter, the dose should be increased by a maximum of 25 mg to 50 mg every 1 to 2 weeks until the optimal response is achieved. The usual maintenance dose to achieve optimal response is 100-200 mg/day given once a day or in two divided doses. In those patients taking enzyme inducing AEDs or other medications that induce lamotrigine glucuronidation with/without other AEDs (except valproate), the initial Lamotrigine Tablets (Lametec DT) dose is 50 mg once a day for two weeks, followed by 100 mg/day given in two divided doses for two weeks. Thereafter, the dose should be increased by a maximum of 100 mg every 1-2 weeks until the optimal response is achieved. The usual maintenance dose to achieve optimal response is 200- 400 mg/day given in two divided doses. Some patients have required 700 mg/day of lamotrigine to achieve the desired response. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT Tablets Dosage The dosage of Lametec DT tablets Lametec DT tablets (Lamotrigine Tablets) is given below: Dosage for Bipolar Disorder Adults (18 years of age and over): Because of the risk of rash, the initial dose and subsequent dose escalation should not be exceeded. Lamotrigine is recommended for use in bipolar patients at risk for a future depressive episode. The recommended initial adult dosage of Lametec DT is 25 mg once daily for 2 weeks, followed by 50 mg once daily for 2 weeks. For Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate Weeks 1 and 2 25 mg daily Weeks 3 and 4 50 mg daily Week 5 100 mg daily Week 6 and 7 200 mg daily © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Lametec DT Tablets (Generic Lamotrigine Tablets) Contraindications Lametec DT is contraindicated in patients with a hypersensitivity to Lamotrigine or any other component of this medication. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Lametec DT Tablets (Generic Lamotrigine Tablets) Storage Instructions Lametec DT tablets (Generic Lamotrigine tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Lametec DT Tablets (Generic Lamotrigine Tablets) Warnings Life-threatening serious rash and/or rash-related death: Discontinue at the first sign of rash, unless the rash is clearly not related to this medicine. Hemophagocytic lymphohistiocytosis: Consider this diagnosis and evaluate patients immediately if they develop signs or symptoms of systemic inflammation. Discontinue Lametec DT if an alternative etiology is not established. Fatal or life-threatening hypersensitivity reaction: Multiorgan hypersensitivity reactions, also known as drug reaction with eosinophilia and systemic symptoms, may be fatal or life threatening. Early signs may include rash, fever, and lymphadenopathy. These reactions may be associated with other organ involvement, such as hepatitis, hepatic failure, blood dyscrasias, or acute multiorgan failure. Lametec must be stopped immediately if alternate etiology for this reaction is not found. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Lametec DT Tablets (Generic Lamotrigine Tablets) Warnings Cardiac rhythm and conduction abnormalities: Based on in vitro findings, Lametec DT could cause serious arrhythmias and/or death in patients with certain underlying cardiac disorders or arrhythmias. Any expected or observed benefit of Lametec DT in an individual patient with clinically important structural or functional heart disease must be carefully weighed against the risk for serious arrythmias and/or death for that patient. Blood dyscrasias (e.g., neutropenia, thrombocytopenia, pancytopenia): May occur, either with or without an associated hypersensitivity syndrome. Monitor the patient for signs of anemia, unexpected infection, or bleeding. Suicidal behavior and ideation: Monitor the patient for suicidal thoughts or behaviors. Aseptic meningitis: Monitor patient for signs of meningitis Medication errors due to product name confusion: Strongly advise patients to visually inspect tablets to verify the received medicine is correct. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Lametec DT Tablets (Generic Lamotrigine Tablets) Side Effects Epilepsy: Most common Lamotrigine tablets (Lametec DT tablets) side effects with an incidence rate of 10% or more in adults were dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, rhinitis, pharyngitis, and rash. Additional adverse reactions (incidence rate of 10% or more) reported in children included vomiting, infection, fever, accidental injury, diarrhea, abdominal pain, and tremor. Bipolar disorder: Most common Lamotrigine tablets (Lametec DT tablets) side effects with an incidence rate greater than 5% in adults were nausea, insomnia, somnolence, back pain, fatigue, rash, rhinitis, abdominal pain, and xerostomia. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Lametec DT Tablets (Generic Lamotrigine Tablets) Overdose Overdoses that have involved up to 15 grams of Lamotrigine have been reported for Lamotrigine Tablets (Lametec DT Tablets), some of which have been fatal. Lamotrigine overdose has resulted in ataxia, nystagmus, increased seizures, decreased level of consciousness, coma, and intraventricular conduction delay. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Lametec DT Tablets (Generic Lamotrigine Tablets) Overdose There are no specific antidotes for Lamotrigine (Lametec DT tablets). Following a suspected overdose, hospitalization of the patient is advised. General supportive care is indicated, including frequent monitoring of vital signs and close observation of the patient. If indicated, emesis should be induced; usual precautions should be taken to protect the airway. It should be kept in mind that Lamotrigine is rapidly absorbed. It is uncertain whether hemodialysis is an effective means of removing Lamotrigine from the blood. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT Tablets During Pregnancy Lamotrigine (Lametec DT tablets) has been classified by the US FDA as Pregnancy Category C. Antiepileptic medications are associated with an increased risk of teratogenicity (the risk is decreased with monotherapy). However, epilepsy itself may be associated with an increased risk of congenital malformations. Data from several prospective pregnancy exposure registries and epidemiological studies of pregnant women have not detected an increased frequency of major congenital malformations or a consistent pattern of malformations among women exposed to Lamotrigine compared with the general population. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Lametec DT Tablets (Generic Lamotrigine Tablets) Lametec DT Tablets During Pregnancy In animal studies, administration of Lamotrigine during pregnancy resulted in developmental toxicity at doses lower than those administered clinically. There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Lametec DT Tablets (Generic Lamotrigine Tablets) For more details on For more details on Lametec DT Tablets click here Lametec DT Tablets click here Lametec DT Tablets (Generic Lamotrigine Tablets) by Cipla Limited, India. © Clearsky Pharmacy ( www.clearskypharmacy.biz )