Depo -Provera Contraceptive Injection (Medroxyprogesterone Acetate CI)

1. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo-Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) is a progestin injectable contraceptive which is used to prevent pregnancy in women 18 years and above. This medication works by preventing the growth and release of an egg (ovulation) during the menstrual cycle. Medroxyprogesterone acetate hinders (in the usual dose range) the secretion of pituitary gonadotropin which, in turn, prevents follicular maturation and ovulation. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Active Ingredient The active ingredient present in Depo- Provera Contraceptive Injection is Medroxyprogesterone Acetate. Each injection (1 ml vial ) contains 150 mg of Medroxyprogesterone Acetate. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Chemical Structure The structure of Medroxyprogesterone Acetate is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo-Provera Contraceptive Injection , manufactured by Pfizer in Belgium is available as 1 ml injection containing 150 mg of Medroxyprogesterone Acetate. ( Website: https://www.pfizer.com/ https://www.pfizer.com/ ) URL: URL: https://www.clearskypharmacy.biz/depo-provera-contraceptive-injection.html https://www.clearskypharmacy.biz/depo-provera-contraceptive-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Medroxyprogesterone Acetate CI – Brand Names Medroxyprogesterone Acetate CI is available under various drug trade names that include Depo-Provera contraceptive injection, Depopolis-150 and Depo Progestin. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Uses of Depo Provera Contraceptive Injection Depo-Provera® (Depot Medroxyprogesterone Acetate) is an injectable birth control method for women. Commonly called the depo shot or birth control shot, this medication is injected into your arm or buttocks. It contains a type of progesterone hormone called Medroxyprogesterone Acetate. Depo-Provera shots provide protection against pregnancy for up to 14 weeks. Depo-Provera CI is given as an injection every three months. Depo- Provera typically suppresses ovulation, keeping your ovaries from releasing an egg. It also thickens cervical mucus to keep sperm from reaching the egg. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo Provera Contraceptive Injection Dosage The dosage of Depo Provera Contraceptive Injection Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) is given below: The recommended dosage of Depo-Provera Contraceptive Injection is 150 mg of Depo-Provera CI every 3 months (13 weeks) administered by deep IM injection in the gluteal or deltoid muscle. The 1 mL vial as well as the 1 mL prefilled syringe of Depo-Provera CI should be vigorously shaken just before use to ensure that the dose being administered represents a uniform suspension. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo Provera Contraceptive Injection Contraindications Depo-Provera Contraceptive Injection is contraindicated in patients with a hypersensitivity to Medroxyprogesterone Acetate or any other component of this medication. Depo-Provera CI is also contraindicated in known or suspected pregnancy or as a diagnostic test for pregnancy, Active thrombophlebitis, or current or past history of thromboembolic disorders, or cerebral vascular disease, Known or suspected malignancy of breast, significant liver disease and undiagnosed vaginal bleeding. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Storage Instructions Depo-Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) has to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Warnings Loss of Bone Mineral Density: Use of Depo-Provera CI decreases serum estrogen levels and is associated with significant loss of bone mineral density (BMD) as bone metabolism accommodates to a lower estrogen level. Bleeding Irregularities: Most women using Depo-Provera Contraceptive Injection experience disruption of menstrual bleeding patterns. Changed menstrual bleeding patterns also include irregular or unpredictable bleeding or spotting, or rarely, heavy or continuous bleeding. Thromboembolic Disorders: The doctor must be alert to the earliest manifestations of thrombotic disorders (thrombophlebitis, pulmonary embolism, cerebrovascular disorders, and retinal thrombosis). Ocular Disorders: Depo-Provera must not be re-administered pending examination in case there is a sudden partial or complete loss of vision or if there is a sudden onset of proptosis, diplopia, or migraine. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Warnings Unexpected Pregnancies: To make sure that Depo-Provera CI is not administered inadvertently to a pregnant woman, the first injection must be given ONLY during the first 5 days of a normal menstrual period; ONLY within the first 5-days postpartum if not breast-feeding, and in case exclusively breast-feeding, ONLY at the sixth postpartum week. Ectopic Pregnancy: Doctors must be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain. Lactation: Detectable amounts of Medroxyprogesterone Acetate have been identified in the milk of mothers receiving Depo Provera Contraceptive Injection. Anaphylaxis and Anaphylactoid Reaction: Anaphylaxis and anaphylactoid reaction have been reported with the use of Depo Provera Contraceptive Injection. In cae an anaphylactic reaction occurs appropriate treatment should be started. Serious anaphylactic reactions require emergency medical treatment. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo Provera Contraceptive Injection Side Effects Most common side effects of Depo-Provera Contraceptive Injection with an incidence rate of greater than 5% are: menstrual irregularities (bleeding or spotting) 57% at 12 months, 32% at 24 months, abdominal pain/discomfort 11%, weight gain more than 10 lbs at 24 months 38%, dizziness 6%, headache 17%, nervousness 11%, decreased libido 6%. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo-Provera Overdose In case of patients with a mild overdose, it is possible that no symptoms may occur. Depo-Provera CI overdose Symptoms are more likely to occur with high doses, or when too much Depo-Provera is used over a long period of time. Symptoms of an overdose can include Headache, Dizziness, Yellowing of the skin or the whites of the eyes (jaundice), Irregular menstruation, such as spotting or heavier or lighter periods, Breast pain, Bloating, Depression and Decreased libido (sex drive). © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Treatment of Depo-Provera Overdose Treatment for a Depo-Provera overdose will normally involve supportive care, which consists of treating the symptoms that occur as a result of an overdose. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) Depo-Provera Contraceptive Injection During Pregnancy Depo-Provera Contraceptive Injection is classified by the US FDA as Pregnancy Category X. This medicine is contraindicated in pregnancy. Depo-Provera CI should not be administered during pregnancy. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Depo Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) For more details on For more details on Depo-Provera Contraceptive Injection click here Depo-Provera Contraceptive Injection click here Depo-Provera Contraceptive Injection (Medroxyprogesterone Acetate CI) by Pfizer (Manufactured in Belgium). © Clearsky Pharmacy ( www.clearskypharmacy.biz )