Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets)

1. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Clofranil (Generic Clomipramine Hydrochloride Tablets) is a tricyclic antidepressant used to treat obsessive compulsive disorder (OCD). It helps decrease persistent/ unwanted thoughts (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that interfere with daily living. The obsessions or compulsions must cause marked distress, be time-consuming, or significantly interfere with social or occupational functioning. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Active Ingredient The active ingredient present in Clofranil tablets is Clomipramine Hydrochloride. Each Clofranil tablet contains 10 mg, 25 mg, 50 mg or 75 mg of Clomipramine. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Chemical Structure The structure of Clomipramine is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Clofranil Tablets are manufactured by Sun Pharmaceutical Industries Limited, India in the strengths of 10 mg, 25 mg, 50 mg and 75 mg SR. ( Website: https://sunpharma.com/ https://sunpharma.com/ ) URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Clomipramine Hydrochloride Tablets – Brand Names Clomipramine Hydrochloride Tablets are available under various drug trade names that include Anafranil Tab, Clofranil Tab, Clofranil-SR Tab, Depnil, Clomilent, Biolomin Tab, Clomidon-25 Tab, Clomidon-SR 75 Tab, Clomidep, Clomistar, Clomifril Tab, Clonil Tab and Clonil-SR Tab. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Uses of Clofranil 10 mg, 25 mg, 50 mg and 75 mg SR Tablets Clofranil (Generic Clomipramine Hydrochloride Tablets) is used to treat obsessive compulsive disorder (OCD). OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious. Clomipramine is a tricyclic antidepressant (TCA). It is thought to work in the brain by increasing the activity of the chemical serotonin. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Clofranil Tablets Dosage The dosage of Clofranil tablets (Clomipramine Hydrochloride tablets) is given below: Depression And Obsessive-Compulsive Syndromes: Depression And Obsessive-Compulsive Syndromes: Start treatment with 50 to 75 mg/day (1 coated tablet of 25 mg 2 to 3 times daily or 1 sustained-release tablet of 75 mg once daily [preferably in the evening]). Raise the daily dosage of Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) stepwise, e.g. 25 mg every few days, (depending on how the medication is tolerated) to 50 to 100 mg, during the first week of treatment. In severe cases this dosage can be increased up to a maximum of 250 mg daily. Once there is a distinct improvement, adjust the daily dosage to a maintenance level of about 50 to 100 mg. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Contraindications Clofranil tablets are contraindicated in patients with a history of hypersensitivity to Clomipramine Hydrochloride or other tricyclic antidepressants. The use of MAOIs intended to treat psychiatric disorders with Clomipramine Hydrochloride or within 14 days of stopping treatment with Clomipramine Hydrochloride is contraindicated because of an increased risk of serotonin syndrome. The use of Clomipramine Hydrochloride within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated. Starting Clomipramine Hydrochloride in a patient who is being treated with linezolid or intravenous Methylene Blue is also contraindicated because of an increased risk of serotonin syndrome. Clomipramine Hydrochloride is contraindicated during the acute recovery period after a myocardial infarction. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Storage Instructions Clofranil tablets (Generic Clomipramine Hydrochloride tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Warnings Clomipramine Hydrochloride tablets (Clofranil tablets) may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. This drug may make you dizzy or drowsy or temporarily blur your vision. Doctors must discuss with patients the risk of taking Clomipramine HCl while engaging in activities in which sudden loss of consciousness could result in serious injury to the patient or others, e.g., the operation of complex machinery, driving, swimming, climbing. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Warnings Seizure was identified as the most significant risk of Clomipramine use. Caution should be used in administering Clomipramine tablets to patients with a history of seizures or other predisposing factors. e.g., brain damage of varying etiology, alcoholism, and concomitant use with other drugs that lower the seizure threshold. Rare reports of fatalities in association with seizures have been reported by foreign post-marketing surveillance, but not in U.S. clinical trials. In some of these cases, Clomipramine had been administered with other epileptogenic medications: in others, the patients involved had possibly predisposing medical conditions. Thus a causal association between Clomipramine treatment and these fatalities has not been established. Since depression is a commonly associated feature of OCD, the risk of suicide should be considered. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Warnings Tricyclic antidepressants, specially in high doses, have been reported to produce sinus tachycardia, changes in conduction time and arrhythmias. A few instances of unexpected death have been reported in patients with cardiovascular disorders. Myocardial infarction and stroke have also been reported with medicines of this class. A variety of withdrawal symptoms have been reported in association with abrupt discontinuation of Clomipramine Hydrochloride tablets (Clofranil tablets) , including dizziness, nausea, vomiting, headache, malaise, sleep disturbance, hyperthermia, and irritability. In addition, such patients may experience a worsening of psychiatric status. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Warnings Before using Clomipramine, tell your doctor or pharmacist your medical history, especially of: blood problems (e.g., purpura, thrombocytopenia), breathing problems (e.g., asthma, chronic bronchitis), personal or family history of glaucoma (angle-closure type), eating disorders (e.g., bulimia), heart problems (e.g., arrhythmias, coronary artery disease, recent heart attack), intestinal problems (e.g., chronic constipation, ileus), liver problems, kidney problems, personal or family history of other mental or mood conditions (e.g., bipolar disorder, schizophrenia), history of hospitalization for a very serious reaction to certain medications (neuroleptic malignant syndrome), heartburn/stomach acid in the esophagus (e.g., due to hiatal hernia), seizures, overactive thyroid (hyperthyroidism), trouble urinating (urinary retention, enlarged prostate), any condition that may increase your risk of seizures (e.g., alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease), certain types of tumors (e.g., pheochromocytoma, neuroblastoma). © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Side Effects The most common side effects of Clomipramine Hydrochloride (Clofranil tablets) and not seen at an equivalent incidence among placebo-treated patients were gastrointestinal complaints, including dry mouth, constipation, nausea, dyspepsia, and anorexia; nervous system complaints, including somnolence, tremor, dizziness, nervousness, and myoclonus; genitourinary complaints, including changed libido, ejaculatory failure, impotence, and micturition disorder; and other miscellaneous complaints, including fatigue, sweating, increased appetite, weight gain, and visual changes. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Side Effects Tell your doctor immediately if you have any serious side effects, including: mental/mood changes (e.g., confusion, depression, memory problems), enlarged/painful breasts, unwanted breast milk production, irregular/painful menstrual periods, muscle stiffness, ringing in the ears, sexual problems (e.g., decreased sexual ability, changes in desire), shakiness (tremors), numbness/tingling of the hands/feet, trouble urinating, easy bruising/bleeding, unusual/uncontrolled movements (especially of the tongue/face/lips), severe stomach/abdominal pain, dark urine, yellowing of eyes/skin. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Overdose Symptoms of Clomipramine Hydrochloride (Clofranil tablets) overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. Other CNS symptoms could possibly include drowsiness, stupor, ataxia, restlessness, agitation, delirium, severe perspiration, hyperactive reflexes, muscle rigidity, and athetoid and choreiform movements. Cardiac abnormalities may include tachycardia, signs of congestive heart failure, and in very rare cases, cardiac arrest. Respiratory depression, cyanosis, shock, vomiting, hyperpyrexia, mydriasis, and oliguria or anuria could also be present. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Overdose Obtain an ECG and immediately begin cardiac monitoring. Protect the patient's airway, establish an intravenous line, and begin gastric decontamination. A minimum of 6 hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is required. In case signs of toxicity occur at any time during this period, extended monitoring is required. There are case reports of patients succumbing to fatal dysrhythmias late after overdose; these patients had clinical evidence of significant poisoning prior to death and most received inadequate gastrointestinal decontamination. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) Clofranil Tablets During Pregnancy Clomipramine Hydrochloride (Clofranil tablets) is classified by the US FDA as Pregnancy Category C. There are no adequate or well-controlled studies conducted in pregnant women. Withdrawal symptoms, including jitteriness, tremor, and seizures, have been reported in neonates whose mothers had taken Clomipramine tablets until delivery. Clomipramine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Clofranil Tablets (Generic Clomipramine Hydrochloride Tablets) For more details on Clofranil Tablets click here Clofranil Tablets click here Clofranil Tablets (Clomipramine Hydrochloride Tablets) by Sun Pharmaceutical Industries Limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html https://www.clearskypharmacy.biz/generic-clomipramine-hydrochloride-tablets.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )