Neurotoxin. Mamba snake. Why Fasciculin ?. Mambas have only Fasciculin Fasciculins : a family of closely related peptides isolated from Mamba venom toxins (FAS-I, FAS-II, and FAS-III)
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
(S atoms are in Cystine amino acid)
The snake neurotoxins act on the neuromuscular junction and block neuromuscular transmission.
Mechanism: By inhibiting acetylcholinesterase and pseudocholinesterase, this neurotoxin allows ACh to build up at its receptors. Thus, they result in enhancement of both muscarinic and nicotinic agonist effect
(Mechanism of Enzyme Action)
Lock and Key
neurotoxin in green
active site in red
snake toxin blockingacetylcholinesterase active site