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Edelfosine-induced Cytochrome c Release in Pancreatic Cancer Cells

Edelfosine-treated pancreatic cancer cells show cytochrome c release into the cytosol over time. Western blot analyses confirm the mitochondrial disruption. This study highlights the impact of edelfosine on mitochondrial function in cancer cells.

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Edelfosine-induced Cytochrome c Release in Pancreatic Cancer Cells

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  1. Figure S2. Edelfosine induces mitochondrial cytochrome c release in different pancreatic cancer cells. Capan-2, CFPAC-1 and HuP-T4 cells were untreated (C) or treated with 20 M edelfosine at the indicated times, and cytochrome c(Cyt c)was detected to be released into the cytosol. Cytochrome c oxidase subunit II (Cyt c Ox. II) and β-actin were analyzed in themitochondrial and cytosolic fractions by Western blotas loading and subcellular fraction controls. Data shown are representative experiments of three performed.

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