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读书报告

读书报告. 胸外二科 研究生 张攀攀. E3 ubiquitin ligase Cbl-b: 泛素连接酶，又称为 E3 泛素连接酶，是一个能够将泛素分子连接到目的 蛋白质 的某个赖氨酸上的酶。 泛素激活酶 E1 、结合酶 E2 以及连接酶 E3 。而其中泛素连接酶 E3 对靶蛋白的特异性识别起关键作用. TAM 受体是一个受体酪氨酸酶亚家族 包括三个成员： Tyro3,Axl,Mer 共同的配体是 Gas6,proteins. Cbl-b mutant NK cells control metastatic melanomas.

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读书报告

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  1. 读书报告 胸外二科 研究生 张攀攀

  2. E3 ubiquitin ligase Cbl-b:泛素连接酶，又称为E3泛素连接酶，是一个能够将泛素分子连接到目的蛋白质的某个赖氨酸上的酶。 • 泛素激活酶E1、结合酶E2以及连接酶E3。而其中泛素连接酶E3对靶蛋白的特异性识别起关键作用

  3. TAM受体是一个受体酪氨酸酶亚家族 • 包括三个成员：Tyro3,Axl,Mer • 共同的配体是Gas6,proteins

  4. Cbl-b mutant NK cells controlmetastatic melanomas

  5. Therapeutic anti-tumour activity ofCbl-b mutant NK cells

  6. TAM receptors are Cbl-b targets and characterization of a TAMreceptor blocker.

  7. Control of metastases by TAM receptor inhibition

  8. 思考： 从人类自热免疫角度发现新的抑制肿瘤的方法

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