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The Life Cycle of an NIH Grant Application. Alicia Dombroski, Ph.D. Deputy Director Division of Extramural Activities NIDCR. A Grant Application Starts with a Great Idea. Who? Scientists at Colleges, Universities, Research Institutes, Small Businesses, Others What?

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The life cycle of an nih grant application l.jpg

The Life Cycle of an NIH Grant Application

Alicia Dombroski, Ph.D.

Deputy Director

Division of Extramural Activities

NIDCR


A grant application starts with a great idea l.jpg
A Grant Application Starts with a Great Idea

  • Who?

    Scientists at Colleges, Universities,

    Research Institutes, Small Businesses,

    Others

  • What?

    Research relevant to human health

    Basic, applied, behavioral,

    translational, clinical


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Types of NIH Applications

  • Research Projects

    • Unsolicited (R01most common)

    • Responding to specific Funding Opportunity Announcement

    • Individual or consortium

  • Small Business Grants

    • Small business innovation research (SBIR)

    • Small business technology transfer (STTR)

  • Training and Career Development

    • Predoctoral, postdoctoral, dual degree, mentored career development, etc.

    • Individual or Institutional


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Preparation of an Application

  • Interaction with NIDCR Program Staff

    • Does the proposed research support the mission of the institute?

    • Is the topic a high priority for the institute?

  • Forms and Instructions online

    • Face page

    • Budget and budget justification

    • Personnel

    • Research plan


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Electronic Submission

Applicant organization must register in Grants.Gov and NIH eRA

Application must be signed and submitted

by a business official at the applicant organization


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Receipt and Referral

Center for Scientific Review (CSR) at NIH receives all

NIH Applications (~80,000 per year)

Determines locus of peer review (CSR or Institute)

Assigns Integrated Review Group (study section)

Assigns Institute based on scientific area


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NIH Peer Review

  • Panel of experts in appropriate scientific areas

  • Applications assigned for critique and discussion

  • Evaluation of scientific and technical merit

  • Meets in person, teleconference, or internet

  • Specific review criteria: Significance, Approach, Innovation, Investigator, Environment

  • Applications are scored (1.0-5.0, with 1.0 best)

  • Investigators receive score and summary statement


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Funding Decisions

  • Factors:

    • Scientific Merit – score, reviewer comments

    • Contribution to the mission of NIDCR

    • Program priorities and portfolio balance

    • Availability of funds

  • Variables:

    • Award period

    • Total amount of award

    • Specific budget items


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Secondary Review

  • National Advisory Dental and Craniofacial Research Council (NADCRC)

    • Advises, consults, makes recommendations

    • Membership:

      • 2 non-voting ex officio (DOD, VA)

      • 13 scientists/clinicians/public

      • 4 year term

    • Applications can only be funded after review by NADCRC and concurrence with initial review outcome


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Other Post-Review Activities

  • Awards administered by NIDCR Grants Management Officer

  • Annual progress reports and financial status reports

  • End of award/competing renewal

  • If Not Funded:

    • Discussions between Applicant and NIDCR Scientific Program Staff

      • Review issues

      • Programmatic issues

      • Resubmission of revised application (up to 2 revisions)

      • Three cycles per year for unsolicited applications

        • Receipt date, review date, council date each cycle


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NIDCR Scientific

Program Staff

Score

Principal

Investigator

Grant Application

Peer Review

NIDCR Grants

Management