MMP’s and Their Role in the Wound - PowerPoint PPT Presentation

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MMP’s and Their Role in the Wound

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  1. MMP’s and Their Role in the Wound Victor L. Sylvia, Ph.D. Associate Professor Department of Orthopaedics University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio, TX 78220

  2. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  3. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  4. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  5. MMPs and Growth Factors • Pathological dysregulation of MMP activity results in excessive breakdown of the extracellular matrix (ECM) and loss of growth factors, involved in normal healing, that are stored in the ECM. • Growth factors such as PDGF-BB, TGF-β and VEGF are found in decreased amounts in chronic wounds, presumably due to the increase in MMPs (Loot et al., 2002; Lerman et al., 2003; Robson et al., 2004).

  6. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  7. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  8. Repair

  9. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  10. Matrix Metalloproteinases and their Substrates

  11. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  12. Remodeling

  13. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  14. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  15. http://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdfhttp://www.med.ufl.edu/IDP/Core/Section%205/IDP%20Grand%20Rounds%20Tissue%20Engineering%202005%20version%203%20compressed.pdf

  16. Effect of Nitric Oxide Donor SNAP on Human Skin Fibroblasts

  17. Effect of Nitric Oxide Donors on MMP-9 Expression

  18. Effect of Nitric Oxide Donors on MMP-8 Expression

  19. Effect of Nitric Oxide Donors on Wound Healing

  20. Questions?