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Insights into Viral Assembly and Entry Mechanisms: Key Inhibitors and Targets

This study delves into the intricate processes of viral assembly and entry, investigating critical factors such as Nucleus, early and late gene expression (GE), and DNA replication mechanisms. It explores the roles of various inhibitors, including Cidofovir, Ribavirin, ST-246, Gleevec, CI-1033, and Rifampin in addressing these processes. The focus on cell-associated enveloped virions (CEV) and unattached enveloped virions (EEV) provides a comprehensive understanding of uncoating and fusion, essential for advancing antiviral strategies.

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Insights into Viral Assembly and Entry Mechanisms: Key Inhibitors and Targets

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  1. Nucleus and ER EV (EEV) VIG Cidofovir Ribavirin Attachment & Fusion ST-246 Gleevec cell accosiated EV (CEV) Early GE DNA-Replication Wrapping Uncoating WV (IEV) Intermediate GE Late GE MV (IMV) unattached EV (EEV) Virion Assembly cell accosiated EV (CEV) CI-1033 Rifampin Protease Inhibitors

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