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生物主題報告

生物主題報告. Long-term potentiation (LTP) and NMD/AMPA 教師 : 周淑娥 教授 組員 : 陳柏銘 B9902059 黃世惠 B9902073. 大綱. 動機. Terje Lømo 發現 LTP LTP VS. LTM 對以後同樣強度的刺激會產生較強烈的反應，且可以維持相當長的時間，故被稱為長效增益作用 (long-term potentiation) 。. Types and Properties.

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生物主題報告

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  1. 生物主題報告 Long-term potentiation (LTP) and NMD/AMPA 教師:周淑娥 教授 組員:陳柏銘B9902059 黃世惠B9902073

  2. 大綱

  3. 動機 • Terje Lømo 發現LTP • LTP VS. LTM • 對以後同樣強度的刺激會產生較強烈的反應，且可以維持相當長的時間，故被稱為長效增益作用(long-term potentiation) 。

  4. Typesand Properties • 在hippocampus有依(1) NMDA receptor(2) metabotropic glutamate receptor • 若以突觸前後神經原分又有以下三種(1) Hebbian LTP (2) Non-Hebbian LTP(3)anti-Hebbian LTP • Input specificity • Associativity • Cooperativity • Persistence

  5. early LTP

  6. early LTP

  7. NMDA

  8. AMPA

  9. Late LTP

  10. Late LTP

  11. LTP與記憶同出一地—海馬迴

  12. 參考資料 http://en.wikipedia.org/wiki/Long-term_potentiation http://en.wikipedia.org/wiki/Hebb%27s_postulate http://en.wikipedia.org/wiki/AMPA_receptor http://en.wikipedia.org/wiki/NMDA_receptor http://www.nature.com/nrn/journal/v8/n2/fig_tab/nrn2055_F4.html http://www.chrisparsons.de/Chris/ampa.htm http://www.chrisparsons.de/Chris/nmda.htm http://www.unmc.edu/physiology/Mann/mann19.html http://en.wikipedia.org/wiki/Long-term_memory

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