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Oral Cancer Early diagnostic and Treatment

Oral Cancer Early diagnostic and Treatment. Professor Igor Reshetov P.A.Hertzen Cancer Research Institute Moscow www.headneckonco.ru. Squamous cell carcinoma of the head and neck (SCCHN): 98 000 new cases in Europe annually. SCCHN: mortality in Europe is 43 000 annually.

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Oral Cancer Early diagnostic and Treatment

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  1. Oral CancerEarly diagnostic and Treatment Professor Igor Reshetov P.A.Hertzen Cancer Research Institute Moscow www.headneckonco.ru

  2. Squamous cell carcinoma of the head and neck (SCCHN): 98 000 new cases in Europe annually SCCHN: mortality in Europe is 43 000 annually SCCHN accounts for 6% of all malignancies Worldwide annual incidence of SCCHN: 485 000 new patients; 261 000 deaths Epidemiology of SCCHN GLOBOCAN 2002 (http://www-dep.iar.fr)

  3. J.Shah 2012 Etiology factors in oral cancer

  4. Reasons for early diagnostic oral cancer

  5. J.Shah 2012 Pathogeneses oral cancer and depends T(tumor)) and N (metastases) factors

  6. J.Shah 2012 Rate of survival in depend with T(tumor) factor

  7. J.Shah 2012 Survival in depend with N(metastases) factor

  8. Sloan-Kettering Cancer Center 2012 Survival in depend with location of tumor

  9. Methods of early diagnostic oral cancer

  10. Possibilities ultra=scope in compare with light endoscopy

  11. White light endoscopy and fluoroscopy – correct vision margins and area Different view in oral mucosa

  12. Mechanism of spectroscope oral mucosa

  13. Confocal laser microscopy New method of morphological diagnostic in vivo tumors on skin and mucosa sensitivity- 88,5% Specifity – 97,6%

  14. Strategy of treatment – innovation new technologies

  15. Sloan-Kettering Cancer Center Rate of survival in depend with possibilities of combine treatment

  16. Molecularly targeted agents in oncology Breast cancer (early, metastatic) Bev, TZB, LAP.. Colo rectal ca (metastatic) Bev, CET, PAN NSCLC (metastatic) Bevacizumab Renal cancer (metastatic) Bev, sunitynib, ewerolimus Sorafenib, TEMSR, HCC (advanced) sorafenib GIST Imatinib Gastric cancer (metastatic) TZB Pancreatic ca (metastatic) erlotinib Brain tumors (advanced) Bev HNSCC (advanced) CET

  17. EGFR Inhibitors • Gefitinib (TKI)- NSCLC • Erlotinib (TKI)- NSCLC, pancreatic ca • Cetuximab (MAB)- colorectal ca, head and neck squamous cell ca, NSCLC • Panitumumab (MAB)- colorectal ca New agents EGFR Receptor Ryc. Materiały informacyjne Amgen

  18. Intraoperative radiotherapy Definition of sentry lymph node Technologies in surgical oncology Electrochemical lysis Photodynamic diagnostic and therapy

  19. Befor treatment Splan cell pappilomas / ВПЧ 6 + 11 типы Combine treatment Electroresection Nd:YAG laser PDD (5Аla) Clinic example P-tС. 16 year.Diagnosis : recurrent pappilomas of larynx with displasia 3 grade Result– 5 years full remission 1 year after.

  20. Robotic-assisted surgery Da Vinci robot–assisted endocrine surgery: Novel applications in otolaryngology Neil Tanna, MD, Arjun S. Joshi, MD, Robert S. Glade, MD, Daniel Zalkind, BS, and Nader Sadeghi, MD, Washington, DC Otolaryngology–Head and Neck Surgery (2006) 135, 633-635

  21. TORS access Transoral robotic surgery Neil G. Hockstein, MD,a,b Bert W. O’Malley, Jr, MDb Operative Techniques in Otolaryngology (2008) 19, 67-71

  22. Trans cervical surgery with trocards of robotic laparoscopic surgery Better orientation and exposition of the tools : Possible surgery of the hypopharynx Advantages ofTORS

  23. Aim – total survival more 90 %

  24. Thank your Attentionwww.headneckonco.ru

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