Brain dysfunction. Jinghua Jin Department of Neurobiology firstname.lastname@example.org. What you have learned about human brain?. Anatomy? Brain structure? Histology? Cell types? Physiology? Brain function? Pharmacology? Central nervous system drugs ?. Outline.
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Department of Neurobiology
To understand the dysfunction of the brain, it’s important to know a bit about the brain…
Specialized Regions of Neurons Carry out Different Functions
Structure of typical mammalian neurons
1. Electrical current travels down the axon
4. The chemicals open up the transport proteins and allow the signal to pass to the next cell
Three characteristics of the brain help it compensate and recover after it has been damaged:
Brodmann Mapping (52 areas)
Patient HM: MRI
HM’s lesion includes medial temporal lope structures in addition to hippocampus
(amygdala, entorhinal cortex…)
The surgery had a profound effect on declarative memory
Severe anterograde amnesia
Mild retrograde amnesia
Disability to transfer new short-term memory into long-term memory
But there was no effect on:
Many forms of memory were spared (short-term memory, motor, implicit memory, etc).
Tyrosine L-DOPA DA