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Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis
Definitions • Lesion: chemical damage in DNA • Mutagens: chemical compounds that cause lesions in DNA which can kill cells and can also increase frequency of mutations in DNA
Specific Repair Pathways • Repair of deaminated bases • Damage due to reactive oxygen • Alkylation of DNA and repair • Pyrimidine dimer repair
Repair of alkylated DNA • Specific N-glycosylases • Methyltransferases
General Repair Mechanisms • Methyl-directed mismatch repair system • Nucleotide excision repair • SOS inducible repair