alzheimer research advances n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
ALZHEIMER RESEARCH ADVANCES PowerPoint Presentation
Download Presentation
ALZHEIMER RESEARCH ADVANCES

Loading in 2 Seconds...

play fullscreen
1 / 38

ALZHEIMER RESEARCH ADVANCES - PowerPoint PPT Presentation


  • 97 Views
  • Uploaded on

ALZHEIMER RESEARCH ADVANCES. JOAN SMITH SONNEBORN, PHD. PROFESSOR EMERITUS UNIVERSITY OF WYOMING ZOOLOGY & PHYSIOLOGY. VIDEO OBJECTIVES 1 VISUALIZATION OF ALZHEIMER’S DISEASE BRAIN; UNDERSTANDING ALZHEIMER’S DISEASE Objective 2

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'ALZHEIMER RESEARCH ADVANCES' - chelsey


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
alzheimer research advances

ALZHEIMER RESEARCH ADVANCES

JOAN SMITH SONNEBORN, PHD.

PROFESSOR EMERITUS

UNIVERSITY OF WYOMING

ZOOLOGY & PHYSIOLOGY

slide2

VIDEO

OBJECTIVES 1

VISUALIZATION OF ALZHEIMER’S DISEASE BRAIN; UNDERSTANDING ALZHEIMER’S DISEASE

Objective 2

ADVANCES IN BRAIN VISUALIZATION IN LIVING PATIENTS

Objective 3

EXERCISE DELAYING MEMORY LOSS USING AN ALZHEIMER MOUSE MODEL

slide3

TOPICS

  • MUST REMOVE STIGMA OF ALZ DISEASE
  • PRODROMAL Alzheimer’s-Earliest Stage.
  • WHERE MICE & NUNS STUDIES MEET
  • REAL CULPRITS STEALING MEMORY? TOXIC AMYLOID; FREE RADICALS
  • HEY! WHY ARE THE ELDERLY TARGETED
  • DIABETES AND ALZHEIMER RELATIONS
slide4

TOPICS (CONTD.)

  • HUMAN DRUG TRIAL UPDATES
  • WHAT SUPPLEMENTS & LIFESTYLES WORK
  • TECHNOLOGIES: NEW DRUGS; NEW BAD GENES
slide6

Plaques & tangles FOUND in nuns & mice not showing memory loss!!

In mice*, memory loss without plaques & tangles.

*Gandy et al.AUG 2010.

slide7

CULPRITS IN ALZHEIMER’S DISEASE

  • TOXIC PARTICLES OLIGOMERS; FREE RADICALS.
slide8

HEY! WHY IN ELDERLY?

  • DECREASE IN PROTECTIVE CELL ENVIRONMENT
  • INCREASE IN DAMAGE ENVIRONMENT
slide9

WHY IN ELDERLY?

  • AGE DEPENDENT DECREASE IN:

1) PROTECTIVE PROTEINS

2) NERVE COMMUNICATION AGENTS

  • AGE DEPENDENT INCREASE IN:

1) TOXIC FRAGMENTS

2) NOX (noxious) ENZYME PRODUCTION.

3) EXPRESSION OF FAMILY OF DAMAGE GENES.

4) GLUTAMATE EXCESS

5) COPPER EXCESS

6)” AGING GENE” EXPRESSION

.

slide10

DIABETES-ALZHEIMER’S:

SHARED PROBLEMS:

  • BOTH HAVE INSULIN RESISTANCE
  • SHOW DECLINE IN KEY ENERGY PATHWAY
  • USE SAME SPLICER TO CUT AMYLOID & INSULIN
  • CONTROL DIABETES; LOSE 5 POUNDS
slide11

HUMAN DRUG TRIALS

  • FLURIZAN, VACCINE TO INDUCE IMMUNITY
  • BAPINEUZUMAB, (PREFORMED ANTIBODY IMMUNE AGENT)
  • PBT2 COPPER TRANSFER
vaccine flurizan targeted a amyloid beta hbo
VACCINE FLURIZAN TARGETED A (AMYLOID BETA) (HBO)
  • INVESTED $200BILLION & 8 YEARS IN FLURIZAN
  • DID SHOW REDUCTION IN PLAQUES & TANGLES BUT HEALTH COMPLICATIONS & NOT SIGNIFICANT EFFECT ON MEMORY LOSS. STUDY DISCONTINUED
recent human trials continued bap pbt2
RECENT HUMAN TRIALS (CONTINUED) BAP; PBT2

USES PREMADE ANTIBODY (BAP),

SUCCESS IN SUBPOPULATION NOT CARRYING SUSCEPTIBILITY GENE APO-E-4 **

Phase 3 trial still in progress.

PBT2 phase 2 : COPPER TRANSPORTER

RESTORES ALZ NEURON PROJECTIONS* & COMMUNICATION PROTEINS LOST IN DISEASE IN MICE

Reduces amyloid, improves function on Neuropsychological test Battery (NTB) in 12 weeks IN HUMANS

*(humanized monoclonal antibody TO AMYLOID)- **1/3 OF ALZ NOT CARRIERS; E 4 INTERFERS WITH TAU STICKING TO MICROTUBLES and susceptibility to oxidation;

Dendritic spine density and synaptic protein levels in a mouse model

Reduces amyloid, improves function on Neuropsychological test Battery NTB in 12 weeks

environment alzheimer s
ENVIRONMENT &ALZHEIMER’S
  • ENVIRONMENTAL ENRICHMENT REDUCES AMYLOID IN MICE MODEL

RESTORES MEMORY IN MOUSE MODEL

NOVELTY , CHANGE IN MENU, CARD GAMES, SCENERY CHANGE, VISITING GROUPS, DANCE INSTRUCTORS, CHILDREN VERSION BINGO GAMES FOR DEMENTIA PATIENTS, ANIMAL VISITS

.

stress reduction
STRESS REDUCTION
  • MUSIC

Ipods with personalized music to soothe or invigorate individual.

SUPPLEMENTS, MINERALS AND FOODS:

Omega 3, Uridine: Like anti -anxiety Drugs Prozac and SSRI

Inositol: Like Valium

EXERCISE

slide16

SUPPLEMENTS?

  • INOSITOL, OMEGA-3 FATTY ACIDS, URIDINE, CURCUMIN, ANTIOXIDANTS, VITAMIN D, C, E, FOLATE, LIPOIC ACID, RESVERATROL
anti depression supplements
ANTI DEPRESSION SUPPLEMENTS,
  • SUPPLEMENTS: URIDINE AND OMEGA-3 TOGETHER MATCHED WITH EFFECTS OF PROZAC AND SSRI’S DRUGS IN MICE*

URIDINE stimulate synthesis of CHOLINE, OMG increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine.

  • URIDINE FOODS: Organ meats (liver, pancreas),Tomatoes, Brewer’s yeast , Beer, **Broccoli
  • Omega 3 (polyunsaturated fats) foods:cold water fish, such as salmon, or flaxseeds, walnuts, winter squash

* . Omega 6 Omega-6s contribute to inflammation in the body, while omega-3 modulates

  • **Carlezon et al., 2005 Biol Psychiatry57 (4): 343–50.
  • ***Yamamoto et al., MetabClin Exp51 (10): 1317–23.
anti alzheimer supplement vitamin d folatee
ANTI ALZHEIMER SUPPLEMENT VITAMIN D & FOLATEe

VITAMIN D : ↑ Transports out cell garbage ,↑ Regulates nerve health pathways; No D intensifies deficit in spatial learning in ALZ patients.**

FOLATE

Required : brain health, function and development

↓ blood pressure and arterial stiffness

Supplement in 60 year olds reduced ALZ risk after 10 years.

Advanced Alzheimer’s Disease lowest folate levels.

Deficiency in institutions & nursing homes: people with absorption problems such as ulcerative colitis and people taking certain medications e.g., methotrexate.

dark green leafy vegetables oranges, lentils, beans, asparagus, broccoli, cauliflower, liver and brewer's yeast.

*

cell membrane and insulation
CELL MEMBRANE AND INSULATION
  • Saturated fats and cholesterol are significant portion of insulation (myelin sheath) around nerve fibers.
  • Born with 100%phosphatidylcholine(lecithin); only have 10% in elderly major constituent of all cell membranes including nerve cells
  • Major Source of lecithin egg yolks
supplements
SUPPLEMENTS
  • INOSITOL,andcholine is lecithin- ingredient in cell membrane, signal processes, increaseacetylcholine and serotonin.↑ positive mood ↓ copper excess, ↑ hair growth.
  • Treats schizophrenia and hypoglycemia. Mimics Valium.
  • Also acetylcysteine: glutamate receptor
anti alz supplements
ANTI-ALZ SUPPLEMENTS

OMEGA-3 FATTY acids ↓ amyloid & tau protein, EPA low in suicide patients, DHA OMG-3s

URIDINE (CHOLINE PRECURSOR): ↑ acetylcholine, repairs synapse membrane in neurons , membrane, damage= dementia

Omega 3 and Uridine supplements are antidepressant, like PROZAC and SSRI in bipolar disorder, reduces amyloid

CURCUMIN (Tumeric,curry, seasoning)*, antioxidant, promotes healthy gene expression.

choline and membrane foods
CHOLINE and membrane FOODS
  • CHOLINE PRECURSOR TO ACETYLCHOLINE
  • Foods with inositol, and uridine
  • Lecithin membrane precursor eggs

.

sirtuins resveratrol
SIRTUINS: RESVERATROL
  • Anti Aging supplement. “ Molecule modifier”srequired for participation/ initiation in major metabolic processes (Deacetylases)
  • Activates “Notch” gene pathway for protection against stress, nerve damage ,and inhibition of enzyme that generates amyloid.
  • Crossed AD mouse with high sirtuin mouse-onset of memory loss delayed*
lipoic acid acetyl carnitine
LIPOIC ACID* & ACETYL CARNITINE

*REDUCED MEMORY DEFICITS IN ALZHEIMER MICE -STRONG ANTIOXIDANT

Acetyl L carnitine : mitochondrial and energy generator, utilizes fatty acid, neuroprotective, memory enhancer; in AD studies

sundowner snack
SUNDOWNER* SNACK?
  • BANANA, PAPYA, DATES (without skin),, ORANGES**, MELON** increase serotonin, and acetylcholine.
  • No wheat or rye

Promotes serotonin (GOOD MOOD) AND breakdown to melatonin (sleep enhancer) –circadian rhythm hormone and “jet lag intervention”

*describes the onset of confusion and agitation that generally affects people with dementia or cognitive impairment and usually strikes around sunset.

** inositol source neuronal membrane and neurotransmitters

chocolate and health
CHOCOLATE AND HEALTH

23.6 million people will die from cardiovascular disorders.

High chocolate consumption (5x/week) associated with 30% risk reduction in: heart diseases, stroke, ie., lowered blood pressure, cholesterol, atherosclerosis, and insulin resistance. Increased brain blood flow in elderly.*Dramatic effect at least in part due to triggering release on Nitric oxide (NO)**

chocolate theobromide
Chocolate & Theobromide

Milk chocolates 20-50% less theobromide (caffeine like chemical) than dark.

Action::diuretic, stimulant, blood pressure relaxer, allows blood flow, relax bronchi muscles in the lungs- used in cough medicine.

Acts on the vagus nerve, which runs from the lungs to the brain.

Poison for dogs and horses and humans that metabolize theobromineslowly, including some elderly.

exercise in elderly
EXERCISE IN ELDERLY
  • Falls: leading cause of injury, death and disability among persons 65 years and older
  • By 2020, falls in over 65 about $43.8 billion/yr.
  • Weight training: increases bone density and bone facture risks. Bone loss 5% per decade after 40. Age associated muscle loss reversible
  • Number of falls from frail women 80 reduced by half in a year with weight training. Some over 90, used cane instead of walker, could get out of chair, and increased mobility.

"ACSM's Health & Fitness Journal"; Benefits of Physical Activity in Older Adults; Angela Fern; Sept/Oct 2009, * Fiatarone Tufts University in Boston

exercise in elderly in nursing home cont
Exercise in Elderly IN NURSING HOME (cont)
  • Reduces prescriptions, doctor visits, emergency calls, orthopedic devices cost, and extent of care needed.
  • Increases mobility and decreases deficits in ADLs; can feed themselves, get out of chair.
  • Improves cognition, mood, and self image.
  • Improves muscle mass, joints, and strength for balance
  • Provides intervention in diabetes, osteoporosis, depression, and obesity and required associated care requirements.
exercises
EXERCISES
  • CHAIR STAND, STANDING LEG CURL, SIDE HIP RAISE, BICEP CURL, OVERHEAD PRESS, UPWARD ROW, TOE STAND** ANKLE & WRIST WEIGHTS
  • LESS FAT,MORE MUSCLE, BONE LOSS PREVENTED OR REVERSES LOSS, INCREASES, STRENGTH, ENERGY , BALANCE, AND FLEXIBILITY.

*Miriam Nelson, Ph.D. 2 “Strong Women Stay Young” 2 sessions/week ISBN 0-553-38077-X

telomeres adult stem cells reprograms
TELOMERES, ADULT STEM CELLS, & REPROGRAMS
  • TELOMERES CAPS ON CHROMOSOMES
  • SHORTER CAPS ≈SHORTER LIFE SPAN
  • REPLACE CAPS, REPAIR &REJUVENATE AGE DAMAGED NEURONS
  • ACTIVATION OF ADULT CELL REGENERATIVE CAPACITY
regenerative medicine
REGENERATIVE MEDICINE
  • TAP INTO HORMETIC RESPONSE (a little bit of bad is good, a lot is bad)
  • Major protective pathways are inducible by stress for repair and regeneration that respond to immediate threat, but repair age damage as well even in the very old.
  • Response can be triggered by known small molecule triggers.
alternative methodlogy aging interventions
ALTERNATIVE METHODLOGY AGING INTERVENTIONS
  • ROLE OF TELOMERES
  • ADULT STEM CELLS
  • HORMESIS
telomere replacement reverses aging
TELOMERE REPLACEMENT REVERSES AGING
  • ENGINEERED AND “KNOCK-OUT” AND INDUCIBLE KNOCK IN” MOUSE
  • RESULT: ACCELLERATION OF AGING REVERSED IN ALL ORGANS BY INDUCING REPLACEMENT OF TELOMERES.
adult stem cells
ADULT STEM CELLS
  • STEM CELLS THROUGHOUT ADULT
  • CAPABLE OF REJUVENATION WITH MASTER SWITCHES SIGNALS
  • BEST SOURCES: UMBILICAL CORD, AMNIOTIC FLUID, WISDOM TEETH, AND GUM TISSUE.
  • DURING DEVELOPMENT DIFFERENTIATION TO CELL TYPE; NOT UNIDIRECTIONAL-CAN REVERSE.
conclusion
CONCLUSION
  • DELAY METABOLIC AGE VULNERABILITY
  • ENHANCE PROTECTION STRATEGIES AGAINST CULPRITS THAT STEAL PRECIOUS MEMORIES.
  • REDUCE CONCENRATION ON PLAQUES AND TANGLES
  • EXPLORE REGENERATIVE STRATEGIES
conclusion hope
CONCLUSION: HOPE

THERE IS REAL PROMISE OF DELAY OF ONSET AND PROGRESSION OF ALZHEIMER’S DISEASE IN OUR IMMEDIATE FUTURE.

slide38

Wyoming Geriatric Education Center

307-766-2829

Please visit our website at:

http://www.uwyo.edu/geriatrics/

______________________________