ALZHEIMER RESEARCH ADVANCES. JOAN SMITH SONNEBORN, PHD. PROFESSOR EMERITUS UNIVERSITY OF WYOMING ZOOLOGY & PHYSIOLOGY. VIDEO OBJECTIVES 1 VISUALIZATION OF ALZHEIMER’S DISEASE BRAIN; UNDERSTANDING ALZHEIMER’S DISEASE Objective 2
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JOAN SMITH SONNEBORN, PHD.
UNIVERSITY OF WYOMING
ZOOLOGY & PHYSIOLOGY
VISUALIZATION OF ALZHEIMER’S DISEASE BRAIN; UNDERSTANDING ALZHEIMER’S DISEASE
ADVANCES IN BRAIN VISUALIZATION IN LIVING PATIENTS
EXERCISE DELAYING MEMORY LOSS USING AN ALZHEIMER MOUSE MODEL
In mice*, memory loss without plaques & tangles.
*Gandy et al.AUG 2010.
1) PROTECTIVE PROTEINS
2) NERVE COMMUNICATION AGENTS
1) TOXIC FRAGMENTS
2) NOX (noxious) ENZYME PRODUCTION.
3) EXPRESSION OF FAMILY OF DAMAGE GENES.
4) GLUTAMATE EXCESS
5) COPPER EXCESS
6)” AGING GENE” EXPRESSION
USES PREMADE ANTIBODY (BAP),
SUCCESS IN SUBPOPULATION NOT CARRYING SUSCEPTIBILITY GENE APO-E-4 **
Phase 3 trial still in progress.
PBT2 phase 2 : COPPER TRANSPORTER
RESTORES ALZ NEURON PROJECTIONS* & COMMUNICATION PROTEINS LOST IN DISEASE IN MICE
Reduces amyloid, improves function on Neuropsychological test Battery (NTB) in 12 weeks IN HUMANS
*(humanized monoclonal antibody TO AMYLOID)- **1/3 OF ALZ NOT CARRIERS; E 4 INTERFERS WITH TAU STICKING TO MICROTUBLES and susceptibility to oxidation;
Dendritic spine density and synaptic protein levels in a mouse model
Reduces amyloid, improves function on Neuropsychological test Battery NTB in 12 weeks
RESTORES MEMORY IN MOUSE MODEL
NOVELTY , CHANGE IN MENU, CARD GAMES, SCENERY CHANGE, VISITING GROUPS, DANCE INSTRUCTORS, CHILDREN VERSION BINGO GAMES FOR DEMENTIA PATIENTS, ANIMAL VISITS
Ipods with personalized music to soothe or invigorate individual.
SUPPLEMENTS, MINERALS AND FOODS:
Omega 3, Uridine: Like anti -anxiety Drugs Prozac and SSRI
Inositol: Like Valium
URIDINE stimulate synthesis of CHOLINE, OMG increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine.
* . Omega 6 Omega-6s contribute to inflammation in the body, while omega-3 modulates
VITAMIN D : ↑ Transports out cell garbage ,↑ Regulates nerve health pathways; No D intensifies deficit in spatial learning in ALZ patients.**
Required : brain health, function and development
↓ blood pressure and arterial stiffness
Supplement in 60 year olds reduced ALZ risk after 10 years.
Advanced Alzheimer’s Disease lowest folate levels.
Deficiency in institutions & nursing homes: people with absorption problems such as ulcerative colitis and people taking certain medications e.g., methotrexate.
dark green leafy vegetables oranges, lentils, beans, asparagus, broccoli, cauliflower, liver and brewer's yeast.
OMEGA-3 FATTY acids ↓ amyloid & tau protein, EPA low in suicide patients, DHA OMG-3s
URIDINE (CHOLINE PRECURSOR): ↑ acetylcholine, repairs synapse membrane in neurons , membrane, damage= dementia
Omega 3 and Uridine supplements are antidepressant, like PROZAC and SSRI in bipolar disorder, reduces amyloid
CURCUMIN (Tumeric,curry, seasoning)*, antioxidant, promotes healthy gene expression.
*REDUCED MEMORY DEFICITS IN ALZHEIMER MICE -STRONG ANTIOXIDANT
Acetyl L carnitine : mitochondrial and energy generator, utilizes fatty acid, neuroprotective, memory enhancer; in AD studies
Promotes serotonin (GOOD MOOD) AND breakdown to melatonin (sleep enhancer) –circadian rhythm hormone and “jet lag intervention”
*describes the onset of confusion and agitation that generally affects people with dementia or cognitive impairment and usually strikes around sunset.
** inositol source neuronal membrane and neurotransmitters
23.6 million people will die from cardiovascular disorders.
High chocolate consumption (5x/week) associated with 30% risk reduction in: heart diseases, stroke, ie., lowered blood pressure, cholesterol, atherosclerosis, and insulin resistance. Increased brain blood flow in elderly.*Dramatic effect at least in part due to triggering release on Nitric oxide (NO)**
Milk chocolates 20-50% less theobromide (caffeine like chemical) than dark.
Action::diuretic, stimulant, blood pressure relaxer, allows blood flow, relax bronchi muscles in the lungs- used in cough medicine.
Acts on the vagus nerve, which runs from the lungs to the brain.
Poison for dogs and horses and humans that metabolize theobromineslowly, including some elderly.
"ACSM's Health & Fitness Journal"; Benefits of Physical Activity in Older Adults; Angela Fern; Sept/Oct 2009, * Fiatarone Tufts University in Boston
*Miriam Nelson, Ph.D. 2 “Strong Women Stay Young” 2 sessions/week ISBN 0-553-38077-X
THERE IS REAL PROMISE OF DELAY OF ONSET AND PROGRESSION OF ALZHEIMER’S DISEASE IN OUR IMMEDIATE FUTURE.
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