S. G 1. G 2. G 0. M. GHIH (or) SST (somatostatin). Hypothalamus:. GHRH. (+). (+). (-). GH (somatotropin). Anterior Pituitary:. (-). Liver:. IGF (somatomedins). Control of Secretion. indirect effects. direct effects. +. +. +. Insulin-like Growth Factor. carbohydrate
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Insulin-like Growth Factor
lipolysis in fat cells
Increases FFA, glycerol, and sugars in circulation
-overproduction of GH
-before puberty: gigantism (excessive growth of long bones)
-in adults: causes excessive growth of cartilage