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Glucose Metabolism Reaction Map in the Presence of Oxygen

Diagram the complete metabolism of glucose to CO2 and H2O in the presence of oxygen, detailing chemical formulas, enzymes, and ATP formation. Track glucose through pathways and predict Krebs Cycle rounds if C1 is labeled.

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Glucose Metabolism Reaction Map in the Presence of Oxygen

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  1. Draw a reaction map of glucose completely metabolized to CO2 + H2O in the presence • of oxygen 25 Points • Reference: http://employee.heartland.edu/hfei/ • Under: • Biol 161-02 / Class Materials / Unit 2 / Lecture Slides / Chapter 8 • Requiresments: • Chemical formula; • Enzymes, co-enzymes, and co-products; 15 points • Calculate ATP formation through aerobic metabolism. Adding up of ATPs from four courses: • direct formation by a reaction • from GTP • from NADH • from FAD2 5 points • Trace C1 of glucose through the pathway as far as you can. 5 points Bonus (2 points): If C1 of glucose is labeled, how many rounds of Krebs Cycle do you expect it to take for it to be completely released as CO2?

  2. Hexokinase p-hexoseisomerase p-fructokinase Glucose-6-Phosphate G6P Fructose-6-Phosphate F6P Fructose-1,6-bisphosphate Glucose Aldolase Glyceraldehyde 3phosphate dehydrogenase Phosphoglyceratekinase Mutase Isomerase Glyceraldehyde 3phosphate Dihydroxy acetone 1,3 bisphosphoglycerate 2-Phosphoglycerate 3-Phosphoglycerate Enolase (SPONTANEOUS) PyruvateKinase Phosphoenopyruvate Enopyruvate Pyruvate CYTOSOL O C -OH MITOCHONDRION C=O CH3 Pyruvate

  3. MITOCHONDRION CITRIC ACID CYCLE CETATE Isocitrate dehydrogenase Aconitase CETATE Isocitrate CETATE CoA Citrate a-Ketoglutarate dehydrogenase a-Ketoglutarate Citrate synthase Pyruvatedehudrogenase complex CETATE Acetyl CoA CETATE Pyruvate Succinyl-CoA SuccinylCoA synthase Oxaloacetate O CETATE C -OH Malatedehydrogenase C=O CETATE CH3 Succinate CETATE SuccinylCoA dehydrogenase Fumarase Malate Fumarate

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