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This study investigates the declining CD4 T-cell counts in HIV-infected patients undergoing antiretroviral therapy with Tenofovir Disoproxil Fumarate (TDF) and Didanosine (ddI). We analyze factors contributing to CD4 depletion and the implications for patient management and treatment optimization. Understanding these trends is crucial for improving clinical outcomes and guiding therapy adjustments in individuals with compromised immune systems.
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