1 / 11

Announcements

Attention BIO 304 students! Please check your clicker ID number (6F28B.19B953) with me to associate it with your name. The upcoming Clicker Quiz 1 on Monday (1/23) will cover key terms and concepts from Chapter 4. Expect practice problems involving gamete and genotype production from given genotypes, pedigree analysis for autosomal recessive traits like cystic fibrosis, and conditional probabilities related to genetic disorders such as Tay-Sachs, Huntington’s, and more. Be prepared!

channer
Download Presentation

Announcements

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Announcements Is this your clicker ID number? 6F28B 19B953 If so, please see me so I can put a name with the number Clicker Quiz 1 on Monday (1/23): will cover key terms and concepts list 2 from Chapter 4 (see course website)

  2. BIO 304 Lecture 4

  3. I. Practice problem: how many gametes or genotypes? How many different gametes can be generated from individuals with the following genotypes? 1. AaBbCc 2. AaBbCcDD How many different genotypes will be produced from the following crosses? 1. AaBbCc X AaBbCc 2. AaBbCc X aabbcc

  4. II. Pedigree analysis

  5. Pedigree of an autosomal recessive trait Mendelian rules apply, but Mendelian ratios are not observed b/c of small sample size Examples: cystic fibrosis, sickle-cell anemia, albinism, Tay-Sachs disease, PKU

  6. Consanguineous marriages can increase the appearance of recessive phenotypes

  7. Pedigree of a dimorphic trait tasters: chemical PTC tastes bitter nontasters: cannot taste PTC at all

  8. Pedigree for an autosomal dominant trait Examples: Huntington’s disease, pseudoachondroplasia (dwarfism), spinocerebellar ataxia type I (SCA1), Marfan’s syndrome, Ehlers-Danlos syndrome, familial hypercholesterolemia, polydactyly

  9. Pedigrees and probability Conditional probability The pedigree below represents the occurrence of cystic fibrosis, a rare autosomal disease. What is the probability that the offspring represented by the question mark will have cystic fibrosis?

  10. *

  11. Using the binomial theorem Two parents are both heterozygous carriers of the autosomal recessive gene that causes Tay-Sachs disease. If the couple has five children, what is the probability that exactly two of the children will have Tay-Sachs disease? Tay Sachs

More Related