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Chagas Disease. Lauren Askew. Chagas disease is characterized by fever, nausea, and diarrhea or constipation and digestive problems.

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Chagas disease

Chagas Disease

Lauren Askew


Chagas disease is characterized by fever nausea and diarrhea or constipation and digestive problems
Chagas disease is characterized by fever, nausea, and diarrhea or constipation and digestive problems

Anna, Moorhouse. "The Fight for Recognition: Chagas’ Disease Meets Controversy" The Journal of Young Investigators12.5 (2005) retrieved 4 November 2012 from http://www.jyi.org/features/ft.php?id=185


20 30 of people infected develop clinically evident disease
20-30% of people infected develop clinically evident disease

Rodriguez, Laura V. “Chagas Disease.” Austin Community College, Web. 30 Oct. 2012. <http://www.austincc.edu/microbio/2993q/tc.htm>.


Chagas is caused by the protozoan parasite trypanosoma cruzi
Chagas is caused by the protozoan parasite Trypanosomacruzi

“TrypanosomaCruzi.” Stanford University, 21 May 2006. Web. 16 Oct. 2012. <http://www.stanford.edu/class/humbio103/ParaSites2006/T_cruzi/>.


The most common mode of transmission is by triatomine bugs
The most common mode of transmission is by triatomine bugs

“New Compounds Active Against Chagas’ Disease Parasite.”Drug Discovery Opinion. 5 Mar. 2009. Web. 16 Oct. 2012. <http://drugdiscoveryopinion.com/2009/03/new-compounds-active-against-chagas%E2%80%99-disease-parasite/>.


In order to survive trypanosoma cruzi transforms itself into four different forms in its lifetime
In order to survive, Trypanosomacruzitransforms itself into four different forms in its lifetime

“Parasites - American Trypanosomiasis (also Known as Chagas Disease).” Center for Disease Control and Prevention, 2 Nov. 2010. Web. 16 Oct. 2012. <http://www.cdc.gov/parasites/chagas/biology.html>.


In the acute phase there is a high concentration of the parasite in the blood stream
In the acute phase, there is a high concentration of the parasite in the blood stream

http://classconnection.s3.amazonaws.com/750/flashcards/748750/jpg/trypanosoma_cruzi_closeup1330800977293.jpg


For the diagnosis of chagas in the acute phase blood smears are used
For the diagnosis of parasite in the blood streamChagas in the acute phase, blood smears are used

“Trypanosomiasis, American.” Laboratory Identification of Parasites of Public Health Concern. Center for Disease Control and Prevention, 20 July 2009. Web. 16 Oct. 2012. <http://www.dpd.cdc.gov/dpdx/HTML/ImageLibrary/TrypanosomiasisAmerican_il.htm>.


The chronic phase is asymptomatic and characterized by few parasites in the blood
The parasite in the blood streamchronic phase is asymptomatic and characterized byfew parasites in the blood

“Chagas ‘disease, Parasitic Disease on the Rise Worldwide.”Pests and Pest Control. 16 June 2012. Web. 16 Oct. 2012. <http://www.pestreport.info/parasites/chagas-disease-parasitic-disease-on-the-rise-worldwide/>.


For the diagnosis of c hagas in the chronic phase we test for the presence of antibodies
For the diagnosis of parasite in the blood streamChagasin the chronic phase, we test for the presence of antibodies

“Products | ELISA | Vircell - ELISA Single Tests.” Vircell Microbiologists, Web. 15 Oct. 2012. <http://en.vircell.com/products/elisa/single_tests/?tx_gtkvircell_pi1%5Buid%5D=299&cHash=40cdeea7b21a29c7854b7ab277dca19b>.


Experiments recently conducted show that adipose tissue is the main target of the protozoa
Experiments recently conducted show that adipose tissue is the main target of the protozoa

Nagajyothi, Fnu, Mahalia S Desruisseaux, and Louis M Weiss. “Chagas Disease, Adipose Tissue and the Metabolic Syndrome.” July 2009. Web. 15 Oct. 2012. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008359/pdf/nihms256472.pdf>.


Chagas was first discovered in 1909
Chagas the Was First Discovered in 1909

Rodriguez, Laura V. “Chagas Disease.” Austin Community College, Web. 30 Oct. 2012. <http://www.austincc.edu/microbio/2993q/tc.htm>.


Chagas is endemic throughout latin america
Chagas the Is Endemic throughout Latin America

http://media.maps101.com/SUB/GITN/ARCHIVES/GIF/811_121605chagas.gif


However north america and europe are being increasingly affected
However, North America and Europe are Being Increasingly Affected

A Angheben, M Anselmi., et al. “ChagasDisease in Italy: Breaking an Epidemiological Silence.” Eurosurveillance, 15 Sept. 2011. Web. 15 Oct. 2012. <http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19969>.


The efforts to reduce the transmission of chagas have been effective
The efforts to reduce the transmission of AffectedChagas have been effective

“Public Health.” Stanford University, Web. 15 Oct. 2012. <http://www.stanford.edu/class/humbio103/ParaSites2006/T_cruzi/publichealth.htm>.


Currently there are two main medications used to treat chagas
Currently, there are two main medications used to treat AffectedChagas

benznidazole

nifurtimox

K Byler, M Brito-Arias , et al. “Identification of Benzoylisoquinolines as Potential anti-Chagas Agents.” Science Direct. Bioorganic & Medicinal Chemistry, 15 Apr. 2012. Web. 15 Oct. 2012. <http://www.sciencedirect.com/science/article/pii/S0968089612001484 >.