1 / 11

Hodgkin Disease

Hodgkin Disease. Definition: neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells. It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare. Disease is associated with defective cellular immunity.

Download Presentation

Hodgkin Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Hodgkin Disease • Definition: neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells. It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare. Disease is associated with defective cellular immunity.

  2. Hodgkin Disease • Incidence: - 2-4 cases per 100000 population / year - bimodal age distribution : 15-35 years and above 50 years - male predominance M:F = 1,7:1

  3. Clinical Presentation • Nontender lymph nodes enlargement ( localised ) • neck and supraclavicular area 60-80% • mediastinal adenopathy 50% • other ( abdominal, extranodal disease ) • systemic symptoms (B symptoms) 30% • fever • night sweats • unexplained weight loss (10% per 6 months) • other symptoms • fatigue, weakness, pruritus • cough , chest pain, shortness of breath, vena cava syndrome • abdominal pain, bowel disturbances, ascites • bone pain

  4. Diagnosis of Hodgkin Disease • is based on microscopic examination of lymph node or other involved tissue • it requires identification of diagnostic Reed-Sternberg cells

  5. Pathologic ClassificationWHO • Classical Hodgkin disease • lymphocyte rich (LR) • nodular sclerosis 1 and 2 (NS) • mixed cellularity (MC) • lymphocyte depletion (LD) • Hodgkin lymphoma with lymphocyte predominance (LP)

  6. Staging Classification Ann Arbor modified by Cotswolds • Stage I: involvement of single lymph node region or lymphoid structure • Stage II: involvement of two or more lymph node regions on same side of diaphragm • Stage III: involvement of lymph node regions or structures on both sides of diaphragm III1: with splenic hilar,celiac,portal nodes III2: with para-aortic,iliac,mesenteric nodes • Stage IV: involvement of extranodal site(s) A. Asymptomatic B. Symptomatic (B symptoms) X. Bulky disease ( > 1/3 widening of mediastinum, > 10cm max.dimension of nodal mass) E. Involvement of a single, localised, extranodal site

  7. Staging evaluation for Hodgkin’s Disease (1) • Essential • pathologic documentation by hemopathologist • physical examination • documentation of B symptoms • laboratory evaluation • complete blood count, ESR • liver function tests • renal function tests • lactate dehydrogenase • chest radiograph • ultrasonography • CT scan of chest, abdomen and pelvis • bone marrow aspiration / biopsy (bilateral)

  8. Staging evaluation for Hodgkin’s Disease (2) • Essential under certain circumstances • liver biopsy • gallium scan • technetium bone scan • bone radiographs • MRI • bipedal lymphangiogram • staging laparotomy • Useful but not essential tests • cell-surface marker phenotypic analysis • gene rearrangement analysis

  9. Treatment of Hodgkin Disesae (1) With appropriate treatment about 85% of patients with Hodgkin disease are curable • I A,B: radiation therapy • II A : combination chemotherapy + radiotherapy • IIB IIIA,B IVA,B : combination chemotherapy (+/- radiotherapy)

  10. Treatment of Hodgkin Disesae (2) • Radiation therapy 80-90% RC • mantle field • paraaortic field • pelvic field dose: 35-40 Gy/T • Combination chemotherapy • ABVD 80% RC • BEACOPP 90% RC

  11. Treatment of Hodgkin Disesae (3) Salvage therapy- resistance, relapse: • Second-line noncross-resistant regimens CR 30-40% DFS 10-25% • DHAP • CEP • EVAP • High dose chemotherapy with autologous stem cell transplantation

More Related