制片人 : 李晓颖 张媛媛 刘青 李芹 娄江华 田续江 刘波 张平 董铿. Tumor Immunity. HISTORY. Tumor Immunity. Tumor antigen is the new antigen produced by tumor cells. It can cause cell immune response and humoral immune response . Types:
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Tumor antigen is the new antigen produced by tumor cells. It can cause cell immune response and humoral immune response .
New protein ,conformation-changed protein, hidden determinants ,etc.
NK cells play important roles in the
early stage of immunity, are the first barrier .
Bind to MHC class I chain-related molecules A/B
MHC class I chain-related molecules A/B
express only on epicelial tumor cells
Perforin / Granzyme pathway
Fas FaslL interaction
1. Activated Mφbind with tumor cell and kill it directly by releasing lysozyme
2. Activated Mφ secrete TNF NO ect cytotoxic molecules to kill tumor indirectly
3. Process and present tumor cell and activate T cells by releasing cytokines ( IL-1,IL-12)
High efficiency in presenting tumor Ag
Promote the T cell to be active and multiply
CD4 +T cell :
Secrete cytokines to activate CD8+ T cell
CD8+ T cell:
1. recognize tumor specifically and kill tumor cells by releasing perforin , granzyme , FasL (bind to Fas on tumor cell
2. secrete cytokines ( e.g. IFN-γ) and kill tumor cells indirectly
3.CDC (complement dependent cytotoxicyty)
4.Close some receptors on the tumor cells
5.Change the adhensin quality of tumor cell
Tumor immunotherapy is a kind of therapy which is to initiate or to enhance the immune function of our body, and then to prevent the tumor cells to diffuse or to kill the tumor cells.
my god !
So magical !
The therapy that stimulate specifical anti-tumor immune response by injecting vaccine
1 Inactivated tumor vaccine
2 Subunit tumor vaccine
3 APC vaccine
Use highly specific mAbs as carriers, coupled with cytotoxic kill molecules to kill tumour cells targetly.
A human Fc attached to a mouse F(ab)2 , reduce the risk of an immune response to the mAbs.
Toxins coupled with mAbs can form immunotoxin and can kill the tumor cells specifically .
Tumor cells may lose some genes or express abnormal genes . Transduce target gene to body and restore the function of tumor cells help them to express normal products.
Body cell gene therapy （ex vivo）
target gene recombined with receptor cell
Inject recombined receptor cell to patient body , so express the exogenous gene in patient
Direct gene therapy
Inject the exogenous gene to the patient body directly, and make it transcript and express .
Induce, activate or multiply the anti-tumor effective cells .Then transfuse the cells to patients to the cause anti-tumor function .
LAK (lymphokine - activated natural killers)
Lymphocytes from periphery blood ,mainly
★Have no MHC restriction
★It is non- specific immunotherapy
★Kill the tumor cells which is not sensitive to
★ NK and CTL
The mechanism of cytokine therapy for tumor is that after being injected into body ,the cytokine can regulate and increase the activity of immune cells ,and have enhance anti-tumor effect. So far, IL-2,IFN-r,TNF-a and CSF have been used for tumor treatment .