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Introduction and benefits

Tubitak: MAM Research Center. Introduction and benefits. Paul Peters 31 Jan 2007. Strategies & challenges within pharma & biotech. Companies searching for more complex solutions in healthcare Need to develop strong clinical candidates

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Introduction and benefits

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  1. Tubitak: MAM Research Center Introduction and benefits Paul Peters 31 Jan 2007

  2. Strategies & challenges within pharma & biotech • Companies searching for more complex solutions in healthcare • Need to develop strong clinical candidates • adopt best practices from both traditional pharmaceutical as well as modern biotechnology • Major attrition in development, especially Phase 2 • Chemistry and biology merging as sciences (genomics, proteomics) • Freedom-to-operate and other intellectual property issues are key drivers of R&D • Strategic information has become a critical business factor to innovate

  3. Chemical Abstracts Service, CAS • CAS... we are scientists, creating and delivering the most complete and effective digital information environment for scientific research and discovery • CAS is a self-sustaining division of the American Chemical Society • CAS employs 1250 staff members in Columbus, Ohio

  4. Chemical Abstracts Service, CAS • CAS Content... the world’s largest collection of chemical and related scientific information for the research community including: • Most authoritative collection of substance information available • Worldwide coverage of current and comprehensive journals and patents

  5. SciFinder content • CAplus from CAS with 27.6 mil references, abstracts and detailed indexing from 1907- • Sources: 9,500 journals, patents from 50 offices, internet journals and preprint servers, conferences, theses and report • Citations from journals and patents 1997- • Registry from CAS with ~88.5 mil substances • Small molecules, biosequences, polymers, inorganics, alloys, complexes • Single compounds have experimental data from InfoChem and CAS and have calculated data from ACDlabs

  6. SciFinder content • CASREACT from CAS with 12.0 mil single and multi-step reactions • From journals and patents, 1907- • ChemCats from CAS with supplier data from >955 catalogues • Screening compounds, fine chemicals and some bulk for 12 mil compounds • Chemlist from CAS with regulatory information • Medline from NLM with 16.5 mil records from 1950- • Sources: 3200 journals

  7. Unique and comprehensive databases: Creating Content

  8. Sample record (i)

  9. Sample record (ii)

  10. Sample record (iii)

  11. Sample record (v)

  12. Sample record in SciFinder • Shows bibliographic details of the patent • Includes patent family data • The CAS abstract for this invention • much more informative than the original abstract • Deep indexing of the relevant subjects and substances by CAS Registry numbers and their respective roles • Examiner citation for this patent

  13. SciFinder functions • Explore literature and patents by: • Substance name, formula or (sub)structure • Topic search with a natural language query • Author name or organization name • Reaction path or functional group transformation • BLAST search for biosequences • List of patent numbers • Specific bibliographic reference • Numerous ways to refine and analyze results • Setting up alerts (Keep me Posted) • Browse table of contents

  14. SciFinder: more than a search • SciFinder has implemented several smart search processes to improve recall of relevant hits: • Research Topic Explore will use automatic searching of different spelling, word endings, word order and synonyms from a dictionary • Author Explore will provide candidates with similar spelling as provided • Structure Explore will automatically find tautomers and metal-containing complexes

  15. 374 Publishers ACS RSC Academic Press Springer Link Am. Inst. Phys. Highwire Publ. US Patent Office MicroPatent 6500+ Journals Elsevier Kluwer Acad. Publ. Karger Publ. Wiley Marcel Dekker Inst. of Physics EBSCO EPO’s Esp@cenet Full Text links to Chemport

  16. The true power of SciFinder • SciFinder is the preferred research tool for scientists in industry and academia • Unmatched content and currency • Ease of use of the interface • Analysis tools that provide additional insights and creativity • Analysis tools that let the user handle larger answer sets effectively

  17. Analysis features for references

  18. Analysis features for references

  19. Analyze feature • Good for analyzing basic document information, for instance • Analyze by most listed author • Analyze by publication year • Analyze by document type • Analyze by company/ organization name • More convenient than Refine, since we see what is available in the answers • Find unexpected terms

  20. Categorize feature • Very useful to organize indexing terms • Controlled terms for processes, biological entities, diseases, technologies, methods, etc. • Substance names in the context of their role in the documents • List all catalysts, reactants, industrial manufactured compounds, compounds with therapeutic use

  21. Categorize on RC metathesis Reactants / Reagents

  22. Categorize on RC metathesis Catalysts

  23. Panorama feature • Based on the same concept of organizing index terms in science categories • Exports two categorize tables to Excel for cross-tabulation of terms • Shows the number of references indexed with terms from the two categories • Choose them wisely to get the most out of Panorama’s data mining capabilities • SF2002 has some pre-worked Panorama sheets

  24. RC metathesis: Panorama of catalysts versus reactants/reagents Select different option from the drop down menus

  25. RC metathesis: Panorama of catalysts versus reactants/reagents

  26. RC metathesis: Panorama of catalysts versus reactants/reagents • Allows you to identify main compounds in ring-closure metathesis reactions • But also combinations that have few or no references • Double-click a cell to get those references • Click the charts button to create a variety of charts and trend lines • Panorama sheet can be saved and re-used

  27. RC metathesis: Publication year trend lines for 5 catalysts

  28. SciFinder benefits • Easy access to largest database covering chemistry and related sciences relevant to drug discovery • Solid look at IP status for substances and processes • Advanced analysis tools to handle larger answer sets in a creative way • Powerful alerting due to high currency of the information • Content and interface designed by scientists for scientists • Big time save not having to run experiments that are well documented in the literature • Big money save not having to continue projects that have already received patent protection by competition

  29. SciFinder for Govt Research • Price structure based on a commitment in a 12 month period • Access at a concurrent user level, each with a maximum number of individual users • 1 ccu up to 40 users; 2 ccu up to 70 users • 3 ccu up to 110 users; 5 ccu up to 200 users • Pricing starts at $66,240 in 2007 • 1 ccu $66,240; 2 ccu $106,200; 3 ccu $159,300; 5 ccu $265,500

  30. SciFinder Govt Research • Usage restrictions • Sharing of loginids is not allowed • Not allowed to do searches for others • Not allowed to do searches for commercial research, including patentability searching • A scientist may not have more than 5,000 records saved on his/her PC • Inactivity timeout of 20 minutes • Access can be limited by IP address

  31. Questions?

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