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近代遺傳學發展之里程碑

1900 - Rediscovery of Mendel’s laws Garrod: Human Genetics Morgan: Chromosome theory 1953 - DNA structure 1970 s - Recombinant DNA 1977 - DNA sequencing methods 1980 - RFLP markers for linkage studies 1983 - Mapping of Huntington disease 1990 - Human Genome Project

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近代遺傳學發展之里程碑

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  1. 1900 - Rediscovery of Mendel’s laws Garrod: Human Genetics Morgan: Chromosome theory 1953 - DNA structure 1970s - Recombinant DNA 1977 - DNA sequencing methods 1980 - RFLP markers for linkage studies 1983 - Mapping of Huntington disease 1990 - Human Genome Project 2001 - Human genome draft sequence 2003 - Human genome finished sequence 近代遺傳學發展之里程碑

  2. Stage II Stage III Stage IV Stage I Positional Cloning before HGP

  3. Gene and Disease- From Simple to ComplexType II Collagen gene and ANFHOncostatin M receptor gene and PCA

  4. Avascular Necrosis of the Femoral Head (ANFH) • Epidemiology • 10,000~20,000 new patients/yr in USA (300,000~600,000 total) • 4,000~5,000 new patients/yr in Taiwan (100,000 total) • Symptoms • Gradual or sudden onset with progressive pain in the groin • Diagnosis • Clinical evaluation, radiography and MRI scan • Stage I, II (cresent sign), III and IV • Treatment • Early stage: core decompression or bone graft • Late stage: hemiathroplasty or arthroplasty

  5. Conditions Associated with Osteonecrosis ANFH, Perthes disease ANFH Perthes disease from the web site of Zimmer, Inc From the web site of Eorthopod.com

  6. Three ANFH Families in Taiwan

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