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Term cancer derives from observation by Hippocrates Cancer is a group of diseases All involve uncontrolled division of the body’s cells. Cancer Basics. Tumors originate from a single cell Mutation that occurs usually in 1 of 2 types of genes: proto-oncogenes or tumor-suppressor genes.

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Presentation Transcript
cancer basics
Term cancer derives from observation by Hippocrates
  • Cancer is a group of diseases
  • All involve uncontrolled division of the body’s cells

Cancer Basics

cancer basics1
Tumors originate from a single cell
  • Mutation that occurs usually in 1 of 2 types of genes: proto-oncogenes or tumor-suppressor genes

Cancer Basics

slide5
The Body’s Natural Defenses

Fig. 12-19

Anchorage dependence

Density-dependent inhibition

Density-dependent inhibition

25 µm

25 µm

(a) Normal mammalian cells

(b) Cancer cells

cancer is a multistep process
Tumors originate from one cell, but as a tumor develops the cells within it can start to change / evolve becoming increasingly unstable!

Cancer is a Multistep Process!

slide9
RADIOLAB!

Famous Tumors 4:25min

  • 1. How is cancer a multistep process? What are some of the “steps” involved?
  • 2. How does evolution / natural selection relate to cancer?
  • 3. Can cancer be contagious?
cancer is a multistep process1
Increased incidence with age
  • Increased incidence with exposure to environmental carcinogen or inherited mutation
  • Lag time between exposure and cancer development

Cancer is a Multistep Process!

cancer s toll
2nd leading cause of death in the U.S.
  • Men have a 1 in 2 lifetime risk of developing cancer; and women have a 1 in 3 risk
  • Only about 25% of all cancers are “hard core”

Cancer’s Toll

new treatments
Immune-mediated tumor destruction
  • http://www.nytimes.com/2011/09/13/health/13gene.html?pagewanted=all

New Treatments?

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