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Towards synthetic 3D dynamic cardiac Imaging Isabelle E. Magnin CREATIS-LRMN

Towards synthetic 3D dynamic cardiac Imaging Isabelle E. Magnin CREATIS-LRMN CNRS UMR 5220, Inserm U 630, Université Lyon 1, Insa-Lyon http://creatis.insa-lyon.fr. CREATIS - LRMN Medical Imaging Center – Lyon http://creatis.insa-lyon.fr. LRMN. 180 people (65 Ph D students).

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Towards synthetic 3D dynamic cardiac Imaging Isabelle E. Magnin CREATIS-LRMN

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  1. Towards synthetic 3D dynamic cardiac Imaging Isabelle E. Magnin CREATIS-LRMN CNRS UMR 5220, Inserm U 630, Université Lyon 1, Insa-Lyon http://creatis.insa-lyon.fr

  2. CREATIS - LRMNMedical Imaging Center – Lyonhttp://creatis.insa-lyon.fr LRMN 180 people (65 Ph D students) Est Hospital • Doua Campus ESRF, Grenoble

  3. LRMN

  4. LRMN Complex Anatomy short axis Long-axis

  5. Magnetic Resonance Imaging (MRI) 1,5 T Siemens Vision LRMN - -

  6.  Multimodal cardiac imaging MRI LRMN Anatomie Siemens, Sonata

  7. LRMN Heart anatomical surfaces and volumes 3D SPECT, XRays or MRI

  8. LRMN 3D multimodal cardiac images 3D deformable finite elements Creatis & INRIA

  9. LRMN Deformable elastic template for 3D segmentation(Quoc Cuong Pham, PhD thesis Creatis, INPG, 2002) Initial template Nodes : 5197, Elements : 22368 9

  10. Medial surface computation LRMN Medialsurface Endocardial surface Mapping functional data onto a surfacic model Medial surface LV LV+RV Epicardialsurface 10

  11. LRMN PET imaging Siemens ECAT 931

  12.  Multimodal cardiac imaging LRMN Metabolism PET transmissionimage FDG PET emission-image

  13. LRMN Rigid PET-MR image registration method Surface-based registration of thorax structures deformable pyramid approach [Lötjönen et al.,1999] MRI transaxial PET transmission 13

  14. LRMN 3D functional cartographies PET (Glucosis uptake) Patient 1 max max 0 0 Patient 2

  15. LRMN Recording Electro-magnetic activity Magneto-cardiography MCG data (10 patients) • BioMag laboratory (Helsinki University Central Hospital, HUCH) • 99-channel MCG device (Neuromag, Helsinki, Finland) 15

  16. LRMN Cartography of the electromagnetic activity (MCG) New 3D Model 2D conventional [Mäkela et al. 2003]

  17. LRMN 3-D Functional cardiac maps L V Electromagnetic field computed from Magnetocardiography (coll. Helsinki LBME) Quantitative perfusion computed from 3-D FDG Positron Emission Tomography (PET) (coll. Cermep, Lyon) 17

  18. Physiology modeling LRMN • modeling organs anatomy, dynamics and physiology • complex elastic and moving structures • electrophysiological models • bio-mechanical model (FEM) • Biological, cellular models

  19. LRMN A new fully-digital anthropomorphic and dynamic thorax/heart model R. Haddad, I.E. Magnin, and P. ClarysseAugust 2007

  20. LRMN Outline • Motivations and objectives • Difficulties • Thorax/ Heart model construction • Multimodality virtual imaging of the heart • Conclusions and Perspectives

  21. LRMN Need for a reference Motivations • Evaluation of cardiac/thoracic image analysis algorithms • Segmentation and motion tracking of cardiac/thoracic structures • Multimodal Image Registration • Thorax and heart image reconstruction in dynamic tomography See: Schaerer et al., Automatic segmentation in MRI sequences,EMBC 2007, SaP1B4.5

  22. A Virtual reference breathing thorax - beating heart model LRMN : In vivo imaging acquisitions Synthetic Imaging Simulated realistic sequences MRI, TEP, CT, US..

  23. LRMN Building the breathing thorax / Beating heart model: 1. MRI Reference image data acquisitions 2. Anatomic 3D static models (thorax & heart) 3. Models animation 4. Models synchronization Breathing thorax/ Beating heart model

  24. LRMN 3. Models animation • Displacement fields fitting : Successive multi-levels non rigid FFD registrations Delhay, PhD thesis 2006 • Deformation of the 3D model

  25. 2D displays of 3D estimated displacement fields (slice at medium level) Magnitude mm 6,00 4,50 3,00 1,50 LRMN 0,00 end-diastole mid-systole early-diastole

  26. LRMN 2 4 6 8 10 12 14 16 18 20 22 24 26 28 Evolution of the LV and LA volumes during the CC

  27. LRMN Dynamic combined Thorax/Heart model

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