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Using Nanotechnology in Medical Imaging and Diagnosis. Alisha Shutler • Introduction to Nanotechnology December 1, 2007. Presentation Outline. Introduction Bioimaging Techniques Medical Uses Nanotechnology’s Role References. Introduction.

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using nanotechnology in medical imaging and diagnosis

Using Nanotechnology in Medical Imaging and Diagnosis

Alisha Shutler • Introduction to Nanotechnology

December 1, 2007

presentation outline
Presentation Outline
  • Introduction
  • Bioimaging Techniques
  • Medical Uses
  • Nanotechnology’s Role
  • References
introduction
Introduction
  • Biomedical imaging has revolutioned the healthcare industry
  • Current popular techniques involve imaging at structural and anatomic level
  • Need to extend imaging to cellular and molecular levels
bioimaging techniques reflection transmission and fluorescence
Bioimaging Techniques: Reflection, Transmission, and Fluorescence
  • Reflection [1]
    • Confocal Microscopy
    • Optical Coherence Tomography (OCT)
  • Transmission [1]
    • Confocal Microscopy
    • Phase Contrast and Dark Field Microscopy
    • Differential Interference Contrast (DIC) Microscopy
  • Fluorescence [1]
    • (Epi)-Fluorescense Microscopy
    • Scanning Optical Microscopy
    • Confocal Microscopy
    • Two-Photon Laser Scanning Microscopy (TPLSM)
    • Total Internal Reflection Fluorescense Microscopy (TIRF)
    • Near-Field Scanning Optical Microscopy (NSOM)
bioimaging techniques reflection transmission and fluorescence5

Fluorescence Imaging of Collagen [2]

Two-Photon Imaging [2]

Bioimaging Techniques: Reflection, Transmission, and Fluorescence
  • Reflection [1]
    • Confocal Microscopy
    • Optical Coherence Tomography (OCT)
  • Transmission [1]
    • Confocal Microscopy
    • Phase Contrast and Dark Field Microscopy
    • Differential Interference Contrast (DIC) Microscopy
  • Fluorescence [1]
    • (Epi)-Fluorescense Microscopy
    • Scanning Optical Microscopy
    • Confocal Microscopy
    • Two-Photon Laser Scanning Microscopy (TPLSM)
    • Total Internal Reflection Fluorescense Microscopy (TIRF)
    • Near-Field Scanning Optical Microscopy (NSOM)
bioimaging techniques getting additional information

Interference Filter [3]

Bioimaging Techniques: Getting Additional Information
  • Spectral Imaging [1]
    • Bandpass Filters
    • Localized Spectroscopy
    • Fluorescence Resonance Energy Transfer (FRET)
  • Time Resolved Imaging [1]
    • Fluorescence Lifetime Imaging (FLIM)
  • Nonlinear Optical Imaging [1]
    • Coherent Anti-Stokes Raman Scattering (CARS)
bioimaging techniques looking ahead
Bioimaging Techniques: Looking Ahead
  • Multifunction Imaging
  • 4Pi Imaging
  • Combination Microscopes
  • Miniaturized Microscopes
medical uses in vivo in vitro ex vivo
Medical Uses: In-vivo, In-vitro,Ex-vivo
  • Cellular Imaging
  • RNA/DNA
  • Protein-Protein Interactions
  • Tissue Imaging
    • Soft Tissue
    • Hard Tissue
  • In-vivo imaging can be used at the level of tissue, organ, or entire live being [1]
medical uses detecting the bad guys

Tumor Cells in a Mouse [2]

Medical Uses: Detecting the Bad Guys
  • Viruses and Bacteria
  • Detection of Tumor Cells
  • Cancer Detection
  • Corneal Imaging
  • Gastrointestinal Pathology
  • Drug Tracking
medical uses looking ahead
Medical Uses: Looking Ahead
  • Future applications of near-IR imaging
  • Use of nanoparticle approach of encapsulation and delivery
  • In-situ activation of a fluorescent probe
  • Real-time in-vivo imaging
  • Imaging of microbes << wavelength of light
nanotechnology s role

Quantum Dots Fluorescence Imaging [2]

Nanotechnology’s Role
  • Light-Matter Interactions
    • Confining light on nanoscale
    • Confining matter on nanoscale
  • Quantum Dots
    • Long lifetimes
    • Not easy to photobleach
    • Insensitive to microbial attack
nanotechnology s role12
Nanotechnology’s Role
  • Bioimaging
  • Biosensing
  • Photodynamic therapy
  • Magnetic nanoclinics
references
References
  • Prasad, Paras N. Biophotonics. New Jersey: John Wiley and Sons, 2003.
  • Cheng, Ji-Xin. “Diagnostic Detection with Fluorescence Spectroscopy and Microscopy.” Perdue University. Fall 2005. <Link>.
  • Nave, C. R. “Interference Filters.” Hyperphysics. 2006. Georgia University. 30 Nov. 2007. <Link>.