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Immunologia dei tumori

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Immunologia dei tumori - PowerPoint PPT Presentation


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Immunologia dei tumori. T umor S pecific T ransplantation A ntigens e T umor A ssociated T ransplantation A ntigens. solo i tumori non immunogenici si sviluppano. si sviluppano i tumori che imparano a resistere al sistema immunitario. Due modelli. cellula bersaglio. MICA/MICB

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Presentation Transcript
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Tumor Specific Transplantation Antigens

e

Tumor Associated Transplantation Antigens

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solo i tumori non immunogenici si sviluppano

si sviluppano i tumori che imparano

a resistere al sistema immunitario

Due modelli

slide8
cellula bersaglio

MICA/MICB

ULBP1,2,3,4

HLA-1

recettori inibitori

recettori attivatori

cellula NK

Attivazione delle cellule NK

Modificata da Backström et al. Scand. J. Immunol. 60:14-22, 2004

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FasL

solubile

IL-10

TGF-

cellule immunitarie

T

T

macrofagi

dendritiche

Fas

cellula tumorale

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Treg

complemento

CCL22

IAPs

CD46, CD55, CD59

membrane-bound

Complement Regulatory Proteins

(mCRPs)

cellula tumorale

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