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Pharmacodynamic Studies and Synthesis of Radiolabeled Nanoparticles for PET Imaging in Inflammation

This study explores pharmacodynamic approaches involving the preparation of radiolabeled nanoparticles for positron emission tomography (PET) studies, specifically focusing on [18F]FDG and [11C]PK11195 in the context of brain inflammation. Additionally, we examine UV spectra of methylene blue in the presence of ZnO nanoparticles and the characterization of TiOx nanoparticles under biologically relevant conditions. DLS imaging and catalytic activity assessments are included, alongside extensive pharmacokinetics studies related to these applications.

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Pharmacodynamic Studies and Synthesis of Radiolabeled Nanoparticles for PET Imaging in Inflammation

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  1. PHARMACODYNAMIC STUDIES Study Control 1- Preparation of [18F]FDG 2- PET study WB INFLAMMATION BRAIN INFLAMMATION 1- Preparation of [11C]PK11195 2- PET study

  2. 2 ____________________________________________________________________________________________________________ Workpackage 1 UV spectra of methylene blue in presence of ZnO nanoparticles ( 1 mg/ml) after being irradiated with UV light for different times Characterization of metal oxide NPs in Biologically relevant conditions and catalytic activity DLS of TiOx nanoparticles in water, NaCl, PBS and cell media

  3. ________________________________________________________________________________________________________________________________________________________________________________________________________________________ Synthesis of radiolabelled NPs for Positron Emission tomography R- detector Pharmacokinetics studies

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